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Cat. No. M3283
Pioglitazone Structure

U 72107

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 65 In stock
50mg USD 117 In stock
100mg USD 177 In stock
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Biological Activity

Pioglitazone (Actos) is a selective peroxisome proliferator-activated receptor gamma stimulator. Pioglitazone (Actos) selectively stimulates the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) and to a lesser extent PPAR-α. Pioglitazone (Actos) modulates the transcription of the insulin-sensitive genes involved in the control of glucose and lipid metabolism in the muscle, adipose tissue, and the liver. As a result, pioglitazone (Actos) reduces insulin resistance in the liver and peripheral tissues. Pioglitazone (Actos) increases the expense of insulin-dependent glucose. Pioglitazone (Actos) decreases withdrawal of glucose from the liver. Pioglitazone (Actos) reduces quantity of glucose, insulin and glycated hemoglobin in the bloodstream.

Product Citations
Customer Product Validations & Biological Datas
Source J Cell Mol Med (2020 Jun). Figure 2. Pioglitazone (Abmole Bioscience, Houston, TX, USA)
Method drug treatments
Cell Lines Neurons
Concentrations 10 μmol/L
Incubation Time 24 hours
Results Compared to the DMSO group, a 24-hour treatment with pioglitazone increased the levels of the ZAG protein (1.013 ± 0.135 vs 0.654 ± 0.090, P = 0.004, n = 4) and AZGP1 mRNA (1.474 ± 0.078 vs 1, P = 0.003, n = 3) (Figure 2B,C), while GW9662 significantly decreased the levels of the ZAG protein (0.361 ± 0.097 vs 0.654 ± 0.090, P = 0.013, n = 4) and AZGP1 mRNA (0.482 ± 0.153 vs 1, P = 0.002, n = 3) (Figure 2B,C).
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 356.44
Formula C19H20N2O3S
CAS Number 111025-46-8
Purity 100.0%
Solubility DMSO 10 mg/mL
Storage at -20°C
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Keywords: Pioglitazone, U 72107 supplier, PPAR, inhibitors

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