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Retinoic acid

Cat. No. M5927
Retinoic acid Structure
Synonym:

Tretinoin; Vitamin A acid; all-trans-Retinoic acid

Size Price Availability Quantity
100mg USD 60 In stock
500mg USD 85 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

All-trans retinoic acid (ATRA; Vitamin A acid) has been widely investigated for treatments of many cancers including prostate cancer.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 300.44
Formula C20H28O2
CAS Number 302-79-4
Purity >99%
Solubility 60 mg/mL in DMSO
Storage at -20°C
References

Retinoic acid and the ocular surface.
Samarawickrama C, et al. Surv Ophthalmol. Surv Ophthalmol.;60(3):183-95. PMID: 25890622.

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Keywords: Retinoic acid, Tretinoin; Vitamin A acid; all-trans-Retinoic acid supplier, PPAR, inhibitors

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