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Etoposide

Cat. No. M2326
Etoposide Structure
Synonym:

Vepesid, MI219

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 40  USD50 In stock
100mg USD 36  USD45 In stock
200mg USD 60  USD75 In stock
500mg USD 116  USD145 In stock
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Quality Control
Biological Activity

Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. Etoposide caused an increase in the mean fluorescence intensity of FasR in both subclones, and an induction of FasL in the ES subclone. Etoposide phosphate is rapidly absorbed and converted to etoposide. Bioavailability averages 68% at doses up to 150 mg/m2/day.

Product Citations
Customer Product Validations & Biological Datas
Source Gene (2015) . Figure .etoposide (Abmole, Shanghai, China)
Method Real time PCR and Western blot
Cell Lines tissue(testis)
Concentrations 0, 30, 60, 90, 120 μM
Incubation Time 0, 6, 12, 18, and 24 h
Results "Es-ADAM10 may be involved in the defense process in vivo at low etoposide concentrations, by the inhibition of spermatid apoptosis. However, Es-ADAM10 might also participate in the regulation of sperm quality. The Es-ADAM10 protein accumulated with etoposide concentration increasing (Fig. 8B). In addition, Es-ADAM10 reached peak at both the mRNA (Fig. 8C) and protein (Fig. 8D) levels after 12 h with 90 μM etoposide, indicating that etoposide induced EsADAM10 in a time- and concentration-dependent manner."
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 588.56
Formula C29H32O13
CAS Number 33419-42-0
Purity 99.39%
Solubility DMSO 42 mg/mL
Storage -20°C, protect from light, sealed
References

[1] Chyuan-Chuan Wu, et al. Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide

[2] K R Hande. Etoposide: four decades of development of a topoisomerase II inhibitor

[3] N C Phillips. Oral etoposide

[4] R A Fleming, et al. Etoposide: an update

[5] K R Hande. Etoposide pharmacology

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Keywords: Etoposide, Vepesid, MI219 supplier, Topoisomerase, inhibitors

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