Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. Etoposide caused an increase in the mean fluorescence intensity of FasR in both subclones, and an induction of FasL in the ES subclone. Etoposide phosphate is rapidly absorbed and converted to etoposide. Bioavailability averages 68% at doses up to 150 mg/m2/day.
Gene. 2015 May 10;117-27.
Identification of ADAM10 and ADAM17 with potential roles in the spermatogenesis of the Chinese mitten crab, Eriocheir sinensis.
Etoposide purchased from AbMole
|Source||Gene (2015) . Figure .etoposide (Abmole, Shanghai, China)|
|Method||Real time PCR and Western blot|
|Concentrations||0, 30, 60, 90, 120 μM|
|Incubation Time||0, 6, 12, 18, and 24 h|
|Results||"Es-ADAM10 may be involved in the defense process in vivo at low etoposide concentrations, by the inhibition of spermatid apoptosis. However, Es-ADAM10 might also participate in the regulation of sperm quality. The Es-ADAM10 protein accumulated with etoposide concentration increasing (Fig. 8B). In addition, Es-ADAM10 reached peak at both the mRNA (Fig. 8C) and protein (Fig. 8D) levels after 12 h with 90 μM etoposide, indicating that etoposide induced EsADAM10 in a time- and concentration-dependent manner."|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 90 mg/mL|
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