Catalog

Topoisomerase Topoisomerase

Inhibitors

Cat.No.	Name	Information
M10542	Alternariol	Alternariol is a mycotoxin produced by Alternaria species. Alternariol inhibits the catalytic activity of topoisomerase I and topoisomerase II enzymes.
M10407	PNU-159682	PNU-159682 is a major active metabolite of nemorubicin (MMDX) in human liver microsomes, it is a highly potent DNA topoisomerase I inhibitor with excellent cytotoxicity. PNU-159682 is a potent ADCs cytotoxin.
M9695	Ellipticine hydrochloride	Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent which inhibits DNA topoisomerase II activities.
M9101	Exatecan mesylate	Exatecan Mesylate is a water soluble topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL).
M9023	Ellipticine	Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor.
M8877	Pixantrone Maleate	Pixantrone dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity.
M7507	10-Hydroxycamptothecin	10-Hydroxycamptothecin is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.
M7505	7-Ethylcamptothecin	7-Ethyl Camptothecin is an anti-cancer chemical that exhibits a strong activity against various murine tumors through Topo I (topoisomerase) inhibition.
M5882	Pirarubicin HCl	Pirarubicin Hcl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II.
M5832	Ofloxacin	Ofloxacin is a synthetic broad-spectrum antimicrobial agent.
M5825	Novobiocin Sodium	Novobiocin Sodium is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria.
M5823	Norfloxacin	Norfloxacin is a broad-spectrum antibiotic.
M5821	Nitroxoline	Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases.
M5737	Levofloxacin hydrate	Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. It acts by inhibiting DNA gyrase (bacterial topoisomerase II).
M5711	Irinotecan hydrochloride	Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.
M5617	Epirubicin HCl	Epirubicin Hcl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase.
M5443	Balofloxacin	Balofloxacin is a quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase.
M4903	Ciprofloxacin	Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
M4860	Idarubicin HCl	Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay.
M4465	Irinotecan	Irinotecan is an inhibitor of Topoisomerase I, and is is activated by hydrolysis to SN-38 (the active metabolite of Irinotecan).
M3989	Vosaroxin	Vosaroxin is a novel first-in-class quinolone derivative that has been developed for use in the treatment of AML as a new-generation topo II inhibitor.
M3784	Genz-644282	Genz 644282 is a novel non-camptothecin topoisomerase I inhibitor with an IC50 value of 0.4 nM in human bone marrow CFU-GM assay.
M3725	TAS-103 dihydrochloride	TAS-103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models.
M3514	Moxifloxacin hydrochloride	Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent.
M3493	Mitoxantrone	Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively
M3313	Teniposide	Teniposide is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL).
M3016	SN-38	SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
M2918	Pefloxacin Mesylate Dihydrate	Pefloxacin Mesylate Dihydrate is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication.
M2707	Flumequine	Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM.
M2453	Beta-Lapachone	Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase.
M2326	Etoposide	Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
M2265	Pirarubicin	Pirarubicin is an anti-neoplastic and inhibitor of Topo II.
M2252	Ellagic acid	Ellagic acid is a selective, ATP-competitive inhibitor of casein kinase 2 (CK2).
M2217	Mitoxantrone dihydrochloride	Mitoxantrone dihydrochloride is a potent inhibitor of topoisomerase II.
M2199	Camptothecin	Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I).
M2144	Topotecan hydrochloride	Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer.
M2089	Irinotecan Hydrochloride Trihydrate	Irinotecan hydrochloride trihydrate is a potent inhibitor of DNA topoisomerase I.
M2057	Dexrazoxane hydrochloride	Dexrazoxane hydrochloride is a Topoisomerase II inhibitor and intracellular ion chelator.
M2001	Idarubicin	Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells.
M1982	Amonafide	Amonafide is a unique ATP-independent Topo II inhibitor that is being studied in the treatment of cancer.
M1969	Doxorubicin HCL	Doxorubicin HCl is an anthracycline antibiotic that inhibits DNA topoisomerase II used in cancer chemotherapy.

Signaling Pathways

Product Type

Topoisomerase Topoisomerase

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