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Abmole Inhibitor Catalog 2017

Topoisomerase Topoisomerase


Cat.No.  Name Information
M10542 Alternariol Alternariol is a mycotoxin produced by Alternaria species. Alternariol inhibits the catalytic activity of topoisomerase I and topoisomerase II enzymes.
M10407 PNU-159682 PNU-159682 is a major active metabolite of nemorubicin (MMDX) in human liver microsomes, it is a highly potent DNA topoisomerase I inhibitor with excellent cytotoxicity. PNU-159682 is a potent ADCs cytotoxin.
M9695 Ellipticine hydrochloride Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent which inhibits DNA topoisomerase II activities.
M9101 Exatecan mesylate Exatecan Mesylate is a water soluble topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL).
M9023 Ellipticine Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor.
M8877 Pixantrone Maleate Pixantrone dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity.
M7507 10-Hydroxycamptothecin 10-Hydroxycamptothecin is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.
M7505 7-Ethylcamptothecin 7-Ethyl Camptothecin is an anti-cancer chemical that exhibits a strong activity against various murine tumors through Topo I (topoisomerase) inhibition.
M5882 Pirarubicin HCl Pirarubicin Hcl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II.
M5832 Ofloxacin Ofloxacin is a synthetic broad-spectrum antimicrobial agent.
M5825 Novobiocin Sodium Novobiocin Sodium is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria.
M5823 Norfloxacin Norfloxacin is a broad-spectrum antibiotic.
M5821 Nitroxoline Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases.
M5737 Levofloxacin hydrate Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. It acts by inhibiting DNA gyrase (bacterial topoisomerase II).
M5711 Irinotecan hydrochloride Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.
M5617 Epirubicin HCl Epirubicin Hcl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase.
M5443 Balofloxacin Balofloxacin is a quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase.
M4903 Ciprofloxacin Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
M4860 Idarubicin HCl Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay.
M4465 Irinotecan Irinotecan is an inhibitor of Topoisomerase I, and is is activated by hydrolysis to SN-38 (the active metabolite of Irinotecan).
M3989 Vosaroxin Vosaroxin is a novel first-in-class quinolone derivative that has been developed for use in the treatment of AML as a new-generation topo II inhibitor.
M3784 Genz-644282 Genz 644282 is a novel non-camptothecin topoisomerase I inhibitor with an IC50 value of 0.4 nM in human bone marrow CFU-GM assay.
M3725 TAS-103 dihydrochloride TAS-103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models.
M3514 Moxifloxacin hydrochloride Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent.
M3493 Mitoxantrone Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively
M3313 Teniposide Teniposide is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL).
M3016 SN-38 SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
M2918 Pefloxacin Mesylate Dihydrate Pefloxacin Mesylate Dihydrate is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication.
M2707 Flumequine Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM.
M2453 Beta-Lapachone Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase.
M2326 Etoposide Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
M2265 Pirarubicin Pirarubicin is an anti-neoplastic and inhibitor of Topo II.
M2252 Ellagic acid Ellagic acid is a selective, ATP-competitive inhibitor of casein kinase 2 (CK2).
M2217 Mitoxantrone dihydrochloride Mitoxantrone dihydrochloride is a potent inhibitor of topoisomerase II.
M2199 Camptothecin Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I).
M2144 Topotecan hydrochloride Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer.
M2089 Irinotecan Hydrochloride Trihydrate Irinotecan hydrochloride trihydrate is a potent inhibitor of DNA topoisomerase I.
M2057 Dexrazoxane hydrochloride Dexrazoxane hydrochloride is a Topoisomerase II inhibitor and intracellular ion chelator.
M2001 Idarubicin Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells.
M1982 Amonafide Amonafide is a unique ATP-independent Topo II inhibitor that is being studied in the treatment of cancer.
M1969 Doxorubicin HCL Doxorubicin HCl is an anthracycline antibiotic that inhibits DNA topoisomerase II used in cancer chemotherapy.

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