| Cat.No. | Name | Information |
|---|---|---|
| M5711 | Irinotecan hydrochloride | Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor. Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. |
| M4903 | Ciprofloxacin | Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM. |
| M4465 | Irinotecan | Irinotecan is an inhibitor of Topoisomerase I, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex. Irinotecan inhibits the growth of LoVo and HT-29 cells, with IC50s of 15.8 ± 5.1 and 5.17 ± 1.4 μM, respectively. |
| M3514 | Moxifloxacin hydrochloride | Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent. |
| M3493 | Mitoxantrone | Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively |
| M3016 | SN-38 | SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. |
| M2326 | Etoposide | Etoposide (VP-16-213) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. |
| M2265 | Pirarubicin | Pirarubicin is an anthracycline that is an inhibitor of Topoisomerase II.*The compound is unstable in solutions, freshly prepared is recommended |
| M2199 | Camptothecin | Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells. |
| M2144 | Topotecan hydrochloride | Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer. |
| M2001 | Idarubicin | Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells. |
| M55538 | Moxifloxacin-d4 | Moxifloxacin-d4 |
| M55211 | F14512 | F14512 is a polyamine-containing inhibitor of DNA topoisomerase II with a broad spectrum of antitumor activities. |
| M41618 | Cholesteryl hemisuccinate | Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. |
| M25614 | Gepotidacin | Gepotidacin (GSK2140944) is a novel, potentially first-in-class, orally active triazaacenaphthylene antibiotic and type II topoisomerase (Topo II) inhibitor.Gepotidacin can selectively inhibit bacterial DNA replication by acting on DNA gyrase (GyrA) and topoisomerase IV (ParC). |
| M25388 | 9-Aminocamptothecin | 9-Aminocamptothecin (9-amino-CPT) is a topoisomerase I inhibitor with potent anticancer activity. 9-Aminocamptothecin inhibits PC-3, PC-3M, DU145, and LNCaP cells with IC50 values of 34.1, 10, 6.5, and 8.9 nM, respectively after 96 h exposure. |
| M22169 | Daunorubicin | Daunorubicin (Daunomycin) is a topoisomerase II inhibitor, it inhibits DNA and RNA synthesis. Daunorubicin is also an anthracycline antibiotic, which can be used in the research of infection and variety of cancers. |
| M20696 | Rubitecan | Rubitecan is a topoisomerase I inhibitor extracted from the bark and leaves of the Camptotheca acuminata tree, which is native to China. Rubitecan is an oral camptothecin with antitumour activity. |
| M20401 | (S)-10-Hydroxycamptothecin | 10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity. |
| M19867 | Gatifloxacin hydrochloride | Gatifloxacin (AM-1155, CG5501, BMS-206584, PD135432) hydrochloride is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases with IC50 of 13.8 μg/ml and 0.109 μg/ml for S. aureus topoisomerase IV and E. coli DNA gyrase, respectively. |
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