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Abmole Inhibitor Catalog 2017

Topoisomerase Topoisomerase

Inhibitors

Cat.No.  Name Information
M5617 Epirubicin HCl Epirubicin Hcl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase.
M5443 Balofloxacin Balofloxacin is a quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase.
M4903 Ciprofloxacin Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
M3989 Vosaroxin Vosaroxin is a novel first-in-class quinolone derivative that has been developed for use in the treatment of AML as a new-generation topo II inhibitor.
M3924 10-Hydroxycamptothecin 10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity.
M3784 Genz-644282 Genz 644282 is a novel non-camptothecin topoisomerase I inhibitor with an IC50 value of 0.4 nM in human bone marrow CFU-GM assay.
M3725 TAS-103 dihydrochloride TAS-103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models.
M3514 Moxifloxacin hydrochloride Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent.
M3493 Mitoxantrone Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively
M3016 SN-38 SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
M2918 Pefloxacin Mesylate Dihydrate Pefloxacin Mesylate Dihydrate is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication.
M2707 Flumequine Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM.
M2453 Beta-Lapachone Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase.
M2326 Etoposide Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
M2265 Pirarubicin Pirarubicin is an anti-neoplastic and inhibitor of Topo II.
M2252 Ellagic acid Ellagic acid is a selective, ATP-competitive inhibitor of casein kinase 2 (CK2).
M2217 Mitoxantrone dihydrochloride Mitoxantrone dihydrochloride is a potent inhibitor of topoisomerase II.
M2199 Camptothecin Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I).
M2144 Topotecan hydrochloride Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer.
M2089 Irinotecan Hydrochloride Trihydrate Irinotecan hydrochloride trihydrate is a potent inhibitor of DNA topoisomerase I.
M2057 Dexrazoxane hydrochloride Dexrazoxane hydrochloride is a Topoisomerase II inhibitor and intracellular ion chelator.
M2001 Idarubicin Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells.
M1982 Amonafide Amonafide is a unique ATP-independent Topo II inhibitor that is being studied in the treatment of cancer.
M1969 Doxorubicin Doxorubicin (trade name Adriamycin) is an anthracycline antibiotic that inhibits DNA topoisomerase II used in cancer chemotherapy.


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