Inhibitors
Cat.No. | Name | Information |
---|---|---|
M9695 | Ellipticine hydrochloride | Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent which inhibits DNA topoisomerase II activities. |
M9101 | Exatecan mesylate | Exatecan Mesylate is a water soluble topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL). |
M9023 | Ellipticine | Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. |
M8877 | Pixantrone Maleate | Pixantrone dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. |
M7507 | 10-Hydroxycamptothecin | 10-Hydroxycamptothecin is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones. |
M7505 | 7-Ethylcamptothecin | 7-Ethyl Camptothecin is an anti-cancer chemical that exhibits a strong activity against various murine tumors through Topo I (topoisomerase) inhibition. |
M5882 | Pirarubicin HCl | Pirarubicin Hcl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II. |
M5832 | Ofloxacin | Ofloxacin is a synthetic broad-spectrum antimicrobial agent. |
M5825 | Novobiocin Sodium | Novobiocin Sodium is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria. |
M5823 | Norfloxacin | Norfloxacin is a broad-spectrum antibiotic. |
M5821 | Nitroxoline | Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases. |
M5737 | Levofloxacin hydrate | Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. It acts by inhibiting DNA gyrase (bacterial topoisomerase II). |
M5711 | Irinotecan hydrochloride | Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. |
M5617 | Epirubicin HCl | Epirubicin Hcl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. |
M5443 | Balofloxacin | Balofloxacin is a quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase. |
M4903 | Ciprofloxacin | Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM. |
M4860 | Idarubicin HCl | Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay. |
M4465 | Irinotecan | Irinotecan is an inhibitor of Topoisomerase I, and is is activated by hydrolysis to SN-38 (the active metabolite of Irinotecan). |
M4463 | Camptothecine | Camptothecine |
M3989 | Vosaroxin | Vosaroxin is a novel first-in-class quinolone derivative that has been developed for use in the treatment of AML as a new-generation topo II inhibitor. |
M3784 | Genz-644282 | Genz 644282 is a novel non-camptothecin topoisomerase I inhibitor with an IC50 value of 0.4 nM in human bone marrow CFU-GM assay. |
M3725 | TAS-103 dihydrochloride | TAS-103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models. |
M3514 | Moxifloxacin hydrochloride | Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent. |
M3493 | Mitoxantrone | Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively |
M3313 | Teniposide | Teniposide is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL). |
M3016 | SN-38 | SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. |
M2918 | Pefloxacin Mesylate Dihydrate | Pefloxacin Mesylate Dihydrate is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication. |
M2707 | Flumequine | Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM. |
M2453 | Beta-Lapachone | Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. |
M2326 | Etoposide | Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. |
M2265 | Pirarubicin | Pirarubicin is an anti-neoplastic and inhibitor of Topo II. |
M2252 | Ellagic acid | Ellagic acid is a selective, ATP-competitive inhibitor of casein kinase 2 (CK2). |
M2217 | Mitoxantrone dihydrochloride | Mitoxantrone dihydrochloride is a potent inhibitor of topoisomerase II. |
M2199 | Camptothecin | Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). |
M2144 | Topotecan hydrochloride | Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer. |
M2089 | Irinotecan Hydrochloride Trihydrate | Irinotecan hydrochloride trihydrate is a potent inhibitor of DNA topoisomerase I. |
M2057 | Dexrazoxane hydrochloride | Dexrazoxane hydrochloride is a Topoisomerase II inhibitor and intracellular ion chelator. |
M2001 | Idarubicin | Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells. |
M1982 | Amonafide | Amonafide is a unique ATP-independent Topo II inhibitor that is being studied in the treatment of cancer. |
M1969 | Doxorubicin HCL | Doxorubicin HCl is an anthracycline antibiotic that inhibits DNA topoisomerase II used in cancer chemotherapy. |
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