Topoisomerase Topoisomerase

Inhibitors

Cat.No.	Name	Information
M1969	Doxorubicin HCL	Doxorubicin HCl (Adriamycin, DOX) hydrochloride is an antibiotic-like agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
M2326	Etoposide	Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
M4465	Irinotecan	Irinotecan is an inhibitor of Topoisomerase I, and is is activated by hydrolysis to SN-38 (the active metabolite of Irinotecan).
M3493	Mitoxantrone	Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively
M2144	Topotecan hydrochloride	Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer.
M20696	Rubitecan	Rubitecan is a topoisomerase I inhibitor extracted from the bark and leaves of the Camptotheca acuminata tree, which is native to China. Rubitecan is an oral camptothecin with antitumour activity.
M20401	(S)-10-Hydroxycamptothecin	10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity.
M20351	WAY-272160	WAY-272160 is a inhibitory activities for topoisomerase II and HER2
M19867	Gatifloxacin hydrochloride	Gatifloxacin (AM-1155, CG5501, BMS-206584, PD135432) hydrochloride is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases with IC50 of 13.8 μg/ml and 0.109 μg/ml for S. aureus topoisomerase IV and E. coli DNA gyrase, respectively.
M13746	Aldoxorubicin	Aldoxorubicin (INNO-206) is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitor), which is released from albumin under acidic conditions.
M13745	Etoposide phosphate	Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands.
M13744	Dxd	Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).
M13743	Daun02	Daun02 is a prodrug of the topoisomerase inhibitor Daunorubicin.
M13742	Karenitecin	Karenitecin (Cositecan) is a topoisomerase I inhibitor, with potent anti-cancer activity.
M13741	Belotecan hydrochloride	Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative.
M13740	Amsacrine	Amsacrine (m-AMSA; acridinyl anisidide) is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells.
M11039	Pyrazoloacridine	Pyrazoloacridine (NSC 366140) has anticancer activity, inhibiting the activity of topoisomerases 1 and 2 (topoisomerases 1 and 2). Pyrazoloacridine (NSC 366140) on K562 in myeloid leukemia cells IC50 The value is 1.25 μM (24 h).
M10993	Berberine chloride hydrate	Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid commonly used as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) production and inhibits DNA topoisomerase. Anti-tumor properties.
M10875	PluriSIn #2	PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs).
M10847	LMP744 hydrochloride	LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA chimeric agent that is an inhibitor of topoisomerase 1 (Top1) with antitumor activity.
M10542	Alternariol	Alternariol is a mycotoxin produced by Alternaria species. Alternariol inhibits the catalytic activity of topoisomerase I and topoisomerase II enzymes.
M10407	PNU-159682	PNU-159682 is a major active metabolite of nemorubicin (MMDX) in human liver microsomes, it is a highly potent DNA topoisomerase I inhibitor with excellent cytotoxicity. PNU-159682 is a potent ADCs cytotoxin.
M9695	Ellipticine hydrochloride	Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent which inhibits DNA topoisomerase II activities.
M9101	Exatecan mesylate	Exatecan Mesylate is a water soluble topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL).
M9023	Ellipticine	Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor.

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Topoisomerase Topoisomerase

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