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Irinotecan hydrochloride

Cat. No. M5711

Irinotecan hydrochloride Structure

Synonym: CPT-11 HCl

Size Price Availability Quantity
50mg USD 80 In stock
100mg USD 125 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Irinotecan hydrochloride prevents DNA from unwinding by inhibition of topoisomerase 1.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 623.14
Formula C33H39ClN4O6
CAS Number 100286-90-6
Purity >99%
Solubility 100 mg/mL in DMSO
Storage at -20°C
References

Irinotecan, a key chemotherapeutic drug for metastatic colorectal cancer.
Fujita K, et al. World J Gastroenterol. 2015 Nov 21;21(43):12234-48. PMID: 26604633.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Irinotecan hydrochloride, CPT-11 HCl supplier, Topoisomerase, inhibitors

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