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Pirarubicin

Cat. No. M2265
Pirarubicin Structure
Synonym:

THP-Adriamycin

Size Price Availability Quantity
10mg USD 60 In stock
50mg USD 230 In stock
100mg USD 400 In stock
200mg USD 550 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Pirarubicin is an analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Pirarubicin is transported into cells vial a sodium-dependent nucleoside transporter. Pirarubicin is used to intercalate DNA and inhibit the activity of topoisomerase II and induce DNA crosslinking.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 627.64
Formula C32H37NO12
CAS Number 72496-41-4
Purity >98%
Solubility DMSO 120 mg/mL
Storage at -20°C
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10-Hydroxycamptothecin

10-Hydroxycamptothecin is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.

7-Ethylcamptothecin

7-Ethyl Camptothecin is an anti-cancer chemical that exhibits a strong activity against various murine tumors through Topo I (topoisomerase) inhibition.

Pirarubicin HCl

Pirarubicin Hcl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Pirarubicin, THP-Adriamycin supplier, Topoisomerase, inhibitors

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