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Topoisomerase Topoisomerase

Cat.No.  Name Information
M2326 Etoposide (VP-16-213) Etoposide (VP-16-213) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
M4465 Irinotecan Irinotecan is an inhibitor of Topoisomerase I, and is is activated by hydrolysis to SN-38 (the active metabolite of Irinotecan).
M3493 Mitoxantrone Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively
M2144 Topotecan hydrochloride Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer.
M3016 SN-38 SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
M2001 Idarubicin Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells.
M2265 Pirarubicin Pirarubicin is an anthracycline that is an inhibitor of Topoisomerase II.*The compound is unstable in solutions, freshly prepared is recommended
M3514 Moxifloxacin hydrochloride Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent.
M4903 Ciprofloxacin Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
M5443 Balofloxacin Balofloxacin is a quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase.
M4860 Idarubicin HCl Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay.
M4403 Groenlandicine Groenlandicine is a proto berberine alkaloid isolated from coptis chinensis. Groenlandicine has moderate inhibition of human recombinant aldose reductase (HRAR) with an IC50 value of 154.2 μM. Groenlandicine induces DNA cleavage mediated by topoisomerase I.
M3989 Vosaroxin Vosaroxin is a novel first-in-class quinolone derivative that has been developed for use in the treatment of AML as a new-generation topo II inhibitor.
M3784 Genz-644282 Genz 644282 is a novel non-camptothecin topoisomerase I inhibitor with an IC50 value of 0.4 nM in human bone marrow CFU-GM assay.
M3725 TAS-103 dihydrochloride TAS-103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models.
M3720 Moxifloxacin Moxifloxacin is an extended-spectrum fluoroquinolone which has improved coverage against gram-positive cocci and atypical pathogens compared with older fluoroquinolone agents, while retaining good activity against gram-negative bacteria.
M3697 Amrubicin Amrubicin is a third-generation anthracycline and potent topoisomerase II inhibitor, showed promising activity in small-cell lung cancer (SCLC) in phase II trials.
M3313 Teniposide Teniposide is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL).
M2918 Pefloxacin Mesylate Dihydrate Pefloxacin Mesylate Dihydrate is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication.
M2707 Flumequine Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM.
M2453 β-Lapachone β-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase.
M2252 Ellagic acid Ellagic acid is a natural antioxidant as well as a potent, ATP-competitive inhibitor of CK2 and SHP2 with IC50 and Ki values of 40 nM and 20 nM, respectively.In addition, Ellagic acid exhibits antiproliferative activity and inhibition of topoisomerase II (Topoisomerase II).
M2217 Mitoxantrone dihydrochloride Mitoxantrone dihydrochloride is a potent inhibitor of topoisomerase II.
M2199 Camptothecin Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells.
M2089 Irinotecan Hydrochloride Trihydrate Irinotecan hydrochloride trihydrate is a potent inhibitor of DNA topoisomerase I.
M2057 Dexrazoxane hydrochloride Dexrazoxane HCl (ICRF-187, ADR-529, DXZ) is an iron chelator that can be used to prevent DOX-induced cardiotoxicity.
M1982 Amonafide Amonafide is a unique ATP-independent Topo II inhibitor that is being studied in the treatment of cancer.
M41622 ICRF-193 ICRF-193 is an TopoII inhibitor.
M41621 Topoisomerase II inhibitor 15 Topoisomerase II inhibitor 15 is a Topoisomerase II inhibitor.




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