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Camptothecin

Cat. No. M2199
Camptothecin Structure
Synonym:

Camptothecin; (S)-(+)-Camptothecin; CPT

Size Price Availability Quantity
50mg USD 60 In stock
100mg USD 80 In stock
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Biological Activity

Camptothecin is a DNA topoisomerase I inhibitor. Camptothecin inhibits topo I by blocking the rejoining step of the cleavage/religation reaction of topo-I, resulting in accumulation of a covalent reaction intermediate, the cleavable complex. Camptothecin induces extensive single strand DNA breaks in reactions containing purified mammalian DNA topoisomerase I. DNA breakage in vitro is immediate and reversible. Camptothecin showed remarkable anticancer activity in preliminary clinical trials.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 348.36
Formula C20H16N2O4
CAS Number 7689-03-4
Purity 99.88%
Solubility DMSO
Storage at -20°C
References

Mechanism of action of camptothecin.
Liu LF, et al. Ann N Y Acad Sci. 2000;922:1-10. PMID: 11193884.

Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro.
Pantazis P, et al. Int J Cancer. 1993 Mar 12;53(5):863-71. PMID: 8449612.

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
Hsiang YH, et al. J Biol Chem. 1985 Nov 25;260(27):14873-8. PMID: 2997227.

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Keywords: Camptothecin, Camptothecin; (S)-(+)-Camptothecin; CPT supplier, Topoisomerase, inhibitors

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