| Cat.No. | Name | Information |
|---|---|---|
| M2326 | Etoposide (VP-16-213) | Etoposide (VP-16-213) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. |
| M4465 | Irinotecan | Irinotecan is an inhibitor of Topoisomerase I, and is is activated by hydrolysis to SN-38 (the active metabolite of Irinotecan). |
| M3493 | Mitoxantrone | Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively |
| M2144 | Topotecan hydrochloride | Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer. |
| M3016 | SN-38 | SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. |
| M2001 | Idarubicin | Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells. |
| M2265 | Pirarubicin | Pirarubicin is an anthracycline that is an inhibitor of Topoisomerase II.*The compound is unstable in solutions, freshly prepared is recommended |
| M3514 | Moxifloxacin hydrochloride | Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent. |
| M4903 | Ciprofloxacin | Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM. |
| M41620 | Topoisomerase II inhibitor 13 | Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. |
| M41619 | ICRF-196 | ICRF-196 is an racemic mixture of the (S,S)- and (R,R)-isomers of ICRF-193. |
| M41618 | Cholesteryl hemisuccinate | Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. |
| M41617 | NBTIs-IN-6 | NBTIs-IN-6 is a bacterial topoisomerase inhibitor with certain antibacterial activity. |
| M41616 | Batracylin | Batracylin (NSC320846) is a potent DNA Topoisomerases I and DNA Topoisomerases II inhibitor. |
| M41615 | Topo II/HDAC-IN-2 | Topo II/HDAC-IN-2 (8d) exhibits excellent dual inhibitory activities against Topo II and HDAC. |
| M41614 | Topo II/HDAC-IN-1 | Topo II/HDAC-IN-1 (7d) exhibits excellent dual inhibitory activities against Topo II and HDAC. |
| M41613 | Topoisomerase II inhibitor 14 | Topoisomerase II inhibitor 14 is a potent inhibtor of Topoisomerase II, with anticancer activity. |
| M41612 | DiPT-4 | DiPT-4 is a dual TOP1/PARP1 inhibitor that induces massive DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells. |
| M41611 | Exatecan mesylate dihydrate | Exatecan (DX-8951) mesylate dihydrate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research. |
| M41610 | Aldoxorubicin hydrochloride | Aldoxorubicin (INNO-206) hydrochloride is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), which is released from albumin under acidic conditions. |
| M41609 | Topoisomerase II inhibitor 16 | Topoisomerase II inhibitor 16 is a selective, orally active, brain-penetrant and irreversible trypanosomal topoisomerase II inhibitor by stabilizing double-stranded DNA:enzyme cleavage complexes. |
| M41274 | Garenoxacin mesylate | Garenoxacin (BMS 284756) mesylate is an orally active quinolone antibiotic. |
| M41011 | NH2-methylpropanamide-Exatecan TFA | NH2-methylpropanamide-Exatecan TFA is a methylpropanamide-modified Exatecan, which is the common ADC Cytotoxin used in the synthesis of ADC. |
| M30893 | Indimitecan | Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities. |
| M30860 | AZD5099 | AZD5099, an antibacterial agent, is a potent and selective bacterial topoisomerase II inhibitor. AZD5099 potently inhibits the infections caused by Gram-positive and fastidious Gram-negative bacteria. |
| M30567 | Bimolane | Bimolane (AT-1727), a human topoisomerase II inhibitor, can be used as an anti-neoplastic agent and for the research of psoriasis. Bimolane shows leukemogenic activity and induces multiple types of chromosomal aberrations in human lymphocytes. |
| M30152 | MC-DOXHZN hydrochloride | MC-DOXHZN ((E/Z)-Aldoxorubicin) hydrochloride is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), with acid-sensitive properties. |
| M30034 | Coralyne chloride | Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage. Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes. |
| M29508 | Doxorubicin | Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication. Doxorubicin inhibits human DNA topoisomerase I with an IC50 of 0.8 μM. |
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