Bimolane (AT-1727), a human topoisomerase II inhibitor, can be used as an anti-neoplastic agent and for the research of psoriasis. Bimolane shows leukemogenic activity and induces multiple types of chromosomal aberrations in human lymphocytes.
| Molecular Weight | 452.5 |
| Formula | C20H32N6O6 |
| CAS Number | 74550-97-3 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] C E Frantz, et al. Cancer Lett. Bimolane: in vitro inhibitor of human topoisomerase II
[3] S Q Chen, et al. Zhongguo Yao Li Xue Bao. [Mutagenic effects of bimolane]
[5] B Xu, et al. J Dermatol. Efficacy of bimolane in the Malassezia ovalis model of psoriasis
| Related Topoisomerase Products |
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| ICRF-196
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