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Ciprofloxacin

Cat. No. M4903
Ciprofloxacin Structure
Synonym:

Bay o 9867

Size Price Availability Quantity
1g USD 60 In stock
5g USD 120 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Ciprofloxacin inhibits topoisomerase IV as a primary topoisomerase target and gyrase as a secondary target.Ciprofloxacin shows an AUC (area under the curve) of 24 μg×h/ml.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 331.34
Formula C17H18FN3O3
CAS Number 85721-33-1
Purity >99%
Solubility DMSO <1 mg/mL
Water <1 mg/mL
Storage at -20°C
References

In vitro activity of Bay 09867, a new quinoline derivative, compared with those of other antimicrobial agents.
Wise R,et.al. Antimicrob Agents Chemother. 1983 Apr;23(4). PMID: 6222695.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ciprofloxacin, Bay o 9867 supplier, Topoisomerase, inhibitors

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