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Mitoxantrone

Cat. No. M3493
Mitoxantrone Structure
Synonym:

Mitozantrone

Size Price Availability Quantity
10mg USD 40  USD40 In stock
50mg USD 55  USD55 In stock
100mg USD 80  USD80 In stock
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Quality Control
Biological Activity

Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 µM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively. It is an anthracenedione (not an anthracycline) antineoplastic agent. It disrupts DNA synthesis and DNA repair in both healthy cells and cancer cells. It is used in the treatment of certain types of cancer, mostly metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin’s lymphoma. It was also shown to improve the survival of children suffering from first relapse of acute lymphoblastic leukaemia. It also engages in intercalation.

Product Citations
Customer Product Validations & Biological Datas
Source J Korean Med Sci (2016). Figure 5. cisplatin, mitoxantrone and topotecan were all purchased from AbMole BioScience Inc. (Houston, USA).
Method CCK8 Assay and ABCG2 ATPase assay
Cell Lines RCSC cells
Concentrations 0~10 μM
Incubation Time 72 h
Results MiR-3163 plays important roles in multidrug resistance (Table 1, Fig. 5A). Results showed that when miR-3163 was overexpressed in RCSCs, the ATPase activity of ABCG2 was significantly downregulated compared to RCSCs with Scramble (Fig. 5B).
Source J Korean Med Sci (2016). Figure 4. cisplatin, mitoxantrone and topotecan were all purchased from AbMole BioScience Inc. (Houston, USA).
Method CCK8 Assay and flow cytometry analysis
Cell Lines RCSC cells
Concentrations 0~10 μM
Incubation Time 72 h
Results A lower proliferation rate was observed in RCSCs transfected with miR-3163 Mimics using the CCK-8 assay (Fig. 4A).RCSCs treated with miR-3163 Mimics were more susceptible to cisplatin-induced apoptosis compared to those treated with Scramble (Fig.4B).
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 444.48
Formula C22H28N4O6
CAS Number 65271-80-9
Purity >98%
Solubility DMSO 80 mg/mL
Storage -20°C, protect from light
References

[1] Abraham Chang. A case of mitoxantrone extravasation

[2] Mirela Enache, et al. Mitoxantrone-Surfactant Interactions: A Physicochemical Overview

[3] Benny J Evison, et al. Mitoxantrone, More than Just Another Topoisomerase II Poison

[4] F Martinelli Boneschi, et al. Mitoxantrone for multiple sclerosis

[5] I Pericot, et al. Mitoxantrone

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Keywords: Mitoxantrone, Mitozantrone supplier, Topoisomerase, inhibitors

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