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Mitoxantrone

Cat. No. M3493

Mitoxantrone Structure
Size Price Availability Quantity
100mg USD 80 In stock
1g USD 280 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 µM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively. It is an anthracenedione (not an anthracycline) antineoplastic agent. It disrupts DNA synthesis and DNA repair in both healthy cells and cancer cells. It is used in the treatment of certain types of cancer, mostly metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin’s lymphoma. It was also shown to improve the survival of children suffering from first relapse of acute lymphoblastic leukaemia. It also engages in intercalation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 444.48
Formula C22H28N4O6
CAS Number 65271-80-9
Purity >99%
Solubility DMSO 80 mg/mL
Storage at -20°C
Customer Product Validations & Biological Datas
Source J Korean Med Sci (2016). Figure 5. cisplatin, mitoxantrone and topotecan were all purchased from AbMole BioScience Inc. (Houston, USA).
Method CCK8 Assay and ABCG2 ATPase assay
Cell Lines RCSC cells
Concentrations 0~10 μM
Incubation Time 72 h
Results MiR-3163 plays important roles in multidrug resistance (Table 1, Fig. 5A). Results showed that when miR-3163 was overexpressed in RCSCs, the ATPase activity of ABCG2 was significantly downregulated compared to RCSCs with Scramble (Fig. 5B).
Rating
Source J Korean Med Sci (2016). Figure 4. cisplatin, mitoxantrone and topotecan were all purchased from AbMole BioScience Inc. (Houston, USA).
Method CCK8 Assay and flow cytometry analysis
Cell Lines RCSC cells
Concentrations 0~10 μM
Incubation Time 72 h
Results A lower proliferation rate was observed in RCSCs transfected with miR-3163 Mimics using the CCK-8 assay (Fig. 4A).RCSCs treated with miR-3163 Mimics were more susceptible to cisplatin-induced apoptosis compared to those treated with Scramble (Fig.4B).
Rating
Product Citations
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Mitoxantrone supplier, Topoisomerase, inhibitors

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