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Moxifloxacin hydrochloride

Cat. No. M3514
Moxifloxacin hydrochloride Structure
Synonym:

BAY12-8039 HCl

Size Price Availability Quantity
1g USD 240 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Moxifloxacin (Avelox, Avalox) is a fourth generation synthetic fluoroquinolone antibacterial agent. Moxifloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase and topoisomerase IV, which is an enzyme necessary to separate bacterial DNA, thereby inhibiting cell replication.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 437.89
Formula C21H24FN3O4.HCl
CAS Number 186826-86-8
Purity >98%
Solubility DMSO 80 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Moxifloxacin hydrochloride, BAY12-8039 HCl supplier, Topoisomerase, inhibitors

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