Triton X-100

Biological Activity

Triton X-100 is a nonionic, non-denaturing detergent suitable for solubilization, isolation and purification of membrane protein complexes. It is chemically indistinguishable from Nonidet P-40.

Product Citations

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  Theranostics. 2022 Jul 7;12(12):5317-5329.

  Recapitulating influenza virus infection and facilitating antiviral and neuroprotective screening in tractable brain organoids
  Triton X-100 purchased from AbMole

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  Molecules . 2022 May 6;27(9):2994.

  Inosine and D-Mannose Secreted by Drug-Resistant Klebsiella pneumoniae Affect Viability of Lung Epithelial Cells
  Triton X-100 purchased from AbMole

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  Front Pharmacol . 2022 Jul 18;13:943111.

  (±)-5-bromo-2-(5-fluoro-1-hydroxyamyl) Benzoate Protects Against Oxidative Stress Injury in PC12 Cells Exposed to H 2 O 2 Through Activation of Nrf2 Pathway
  Triton X-100 purchased from AbMole

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  Nucleic Acids Res. 2022 Aug 12;50(14):7938-7958.

  HDAC1 and PRC2 mediate combinatorial control in SPI1/PU.1-dependent gene repression in murine erythroleukaemia
  Triton X-100 purchased from AbMole

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  Oxid Med Cell Longev . 2022 Jul 18;2022:5961123.

  Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE
  Triton X-100 purchased from AbMole

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  Cell Death Dis. 2022 Apr 5;13(4):303.

  KLF5 inhibition overcomes oxaliplatin resistance in patient-derived colorectal cancer organoids by restoring apoptotic response
  Triton X-100 purchased from AbMole

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  Front Pharmacol. 2021 Feb 16;12:625074.

  Saikosaponin D Rescues Deficits in Sexual Behavior and Ameliorates Neurological Dysfunction in Mice Exposed to Chronic Mild Stress
  Triton X-100 purchased from AbMole

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  Nanoscale. 2021 May 13;13(18):8614-8622.

  Ordered inverse-opal scaffold based on bionic transpiration to create a biomimetic spine
  Triton X-100 purchased from AbMole

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  Neural Plast. 2021 Apr 19;2021:6680192.

  The Wnt/ β-Catenin Pathway Regulated Cytokines for Pathological Neuropathic Pain in Chronic Compression of Dorsal Root Ganglion Model
  Triton X-100 purchased from AbMole

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  Int J Chron Obstruct Pulmon Dis. 2021 Jun 4;16:1661-1675.

  Histone Deacetylase 2 Suppresses Skeletal Muscle Atrophy and Senescence via NF-κB Signaling Pathway in Cigarette Smoke-Induced Mice with Emphysema
  Triton X-100 purchased from AbMole

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  Front Pharmacol. 2021 May 17;12:589273.

  Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway
  Triton X-100 purchased from AbMole

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  DNA Cell Biol. 2021 Jul;40(7):895-905.

  AEG-1 Knockdown Sensitizes Glioma Cells to Radiation Through Impairing Homologous Recombination Via Targeting RFC5
  Triton X-100 purchased from AbMole

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  Nat Commun. 2020 Sep 15;11(1):4629.

  Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity
  Triton X-100 purchased from AbMole

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  Front Immunol. 2020 Oct 14;11:571959.

  Threonyl-tRNA Synthetase Promotes T Helper Type 1 Cell Responses by Inducing Dendritic Cell Maturation and IL-12 Production via an NF-κB Pathway
  Triton X-100 purchased from AbMole

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  Exp Cell Res. 2020 Nov 1;396(1):112237.

  LRTM1 promotes the differentiation of myoblast cells by negatively regulating the FGFR1 signaling pathway
  Triton X-100 purchased from AbMole

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  2020 Sep.

  Developing a model to assess the contribution of cytokeratin 19-expressing cells during multipotent stromal cell-induced islet regeneration
  Triton X-100 purchased from AbMole

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  Nat Biomed Eng. 2020 Sep;4(9):875-888.

  Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies
  Triton X-100 purchased from AbMole

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  Front Oncol. 2020 May 21;10:667.

  Downregulation of TET1 Promotes Bladder Cancer Cell Proliferation and Invasion by Reducing DNA Hydroxymethylation of AJAP1
  Triton X-100 purchased from AbMole

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  Drug Chem Toxicol. 2016 Oct;39(4):392-9.

  Effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage
  Triton X-100 purchased from AbMole

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  Neurochem Res. 2020 Sep;45(9):2020-2031.

  MCC950 Inhibits NLRP3 Inflammasome and Alleviates Axonal Injures in Early Stages of Diffuse Axonal Injury in Rats
  Triton X-100 purchased from AbMole

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  Environ Health Perspect. 2020 Jun;128(6):67008.

  Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation
  Triton X-100 purchased from AbMole

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  Life Sci. 2020 Sep 15;257:118021.

  TRIB3 destabilizes tumor suppressor PPARα expression through ubiquitin-mediated proteasome degradation in acute myeloid leukemia
  Triton X-100 purchased from AbMole

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  Anat Rec (Hoboken). 2020 Jan 21.

  Resibufogenin inhibited colorectal cancer cell growth and tumorigenesis through triggering ferroptosis and ROS production mediated by GPX4 inactivation
  Triton X-100 purchased from AbMole

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  Sci Adv. 2020 Jul 10;6(28):eaba7260.

  A basal-bolus insulin regimen integrated microneedle patch for intraday postprandial glucose control
  Triton X-100 purchased from AbMole

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  Aging (Albany NY). 2020 Jun 9;12(11):11025-11041.

  LncRNA ADAMTS9-AS2 inhibits gastric cancer (GC) development and sensitizes chemoresistant GC cells to cisplatin by regulating miR-223-3p/NLRP3 axis
  Triton X-100 purchased from AbMole

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  PLoS Pathog. 2020 Apr 13;16(4):e1008498.

  Intestinal Restriction of Salmonella Typhimurium Requires caspase-1 and caspase-11 Epithelial Intrinsic Inflammasomes
  Triton X-100 purchased from AbMole

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information

References

[1] Harendra S, et al. J Environ Sci. Sorption and transport studies of cetyl trimethylammonium bromide (CTAB) and Triton X-100 in clayey soil.

[2] Zhao B, et al. Water Sci Technol. Micellar-enhanced ultrafiltration of copper ions using sodium dodecyl sulfate and its mixture with Brij 35, Tween 80 and Triton X-100.