Triton x-100

Biological Activity

Triton x-100 is a nonionic, non-denaturing detergent suitable for solubilization, isolation and purification of membrane protein complexes.It is chemically indistinguishable from Nonidet P-40.

Product Citations

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  PLoS Pathog. 2020 Apr 13;16(4):e1008498.

  Intestinal Restriction of Salmonella Typhimurium Requires caspase-1 and caspase-11 Epithelial Intrinsic Inflammasomes
  Triton x-100 purchased from AbMole

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information

References

Sorption and transport studies of cetyl trimethylammonium bromide (CTAB) and Triton X-100 in clayey soil.
Harendra S, et al. J Environ Sci. 2013 Mar 1;25(3):576-84. PMID: 23923432.

Micellar-enhanced ultrafiltration of copper ions using sodium dodecyl sulfate and its mixture with Brij 35, Tween 80 and Triton X-100.
Zhao B, et al. Water Sci Technol. 2013;67(10):2154-9. PMID: 23676382.