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G15

Cat. No. M7871
G15 Structure
Synonym:

G-15

Size Price Availability Quantity
2mg USD 45  USD50 In stock
10mg USD 135  USD150 In stock
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Quality Control
Biological Activity

G15 inhibits GPER-mediated proliferation stimulated by 17β-estradiol (E2) in A549 and H1793 cell lines. G15 also inhibits the response of GPER stimulated by E2 and G1 in A549 and H1793 cell lines. G15 (1.46 mg/kg; i.h.; twice a week for 14 weeks) decreases the number of tumor nodules and tumor index increased by the E2 or G1 group in urethane-induced adenocarcinoma mice.

Product Citations
Customer Product Validations & Biological Datas
Source ECOTOX ENVIRON SAFE 2021 Jan. Figure 6. G15 (Abmole Bioscience Inc, Houston, TX, USA)
Method cell culture
Cell Lines KGN cells
Concentrations 5 μM
Incubation Time 1h
Results We found that G15 (a GPER inhibitor) pretreatment significantly inhibited BPA-induced apoptosis of KGN cells, while MPP (an ERα inhibitor) and PHTPP (an ERβ inhibitor) pretreatment had no significant inhibitory effect on apoptosis
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 370.24
Formula C19H16BrNO2
CAS Number 1161002-05-6
Purity 100.00%
Solubility DMSO ≥ 20 mg/mL
Storage -20°C, protect from light, dry, sealed
References

Estrogen Signaling in ERα-Negative Breast Cancer: ERβ and GPER.
Girgert R, et al. Front Endocrinol (Lausanne). 2019 Jan 9;9:781. PMID: 30687231.

G-Protein-Coupled Estrogen Receptor Antagonist G15 Decreases Estrogen-Induced Development of Non-Small Cell Lung Cancer.
Liu C, et al. Oncol Res. 2019 Feb 21;27(3):283-292. PMID: 28877783.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: G15, G-15 supplier, Estrogen Receptor, inhibitors

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