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G15

Cat. No. M7871
G15 Structure
Synonym:

G-15

Size Price Availability Quantity
10mg USD 150 In stock
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Quality Control
Biological Activity

G15 inhibits GPER-mediated proliferation stimulated by 17β-estradiol (E2) in A549 and H1793 cell lines. G15 also inhibits the response of GPER stimulated by E2 and G1 in A549 and H1793 cell lines. G15 (1.46 mg/kg; i.h.; twice a week for 14 weeks) decreases the number of tumor nodules and tumor index increased by the E2 or G1 group in urethane-induced adenocarcinoma mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 370.24
Formula C19H16BrNO2
CAS Number 1161002-05-6
Purity 100.00%
Solubility DMSO ≥ 20 mg/mL
Storage -20°C, protect from light, dry, sealed
References

Estrogen Signaling in ERα-Negative Breast Cancer: ERβ and GPER.
Girgert R, et al. Front Endocrinol (Lausanne). 2019 Jan 9;9:781. PMID: 30687231.

G-Protein-Coupled Estrogen Receptor Antagonist G15 Decreases Estrogen-Induced Development of Non-Small Cell Lung Cancer.
Liu C, et al. Oncol Res. 2019 Feb 21;27(3):283-292. PMID: 28877783.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: G15, G-15 supplier, Estrogen Receptor, inhibitors

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