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Estrogen Receptor Estrogen Receptor

Cat.No.  Name Information
M7871 G15 G15 is a high affinity and selective G-protein-coupled estrogen receptor (GPER/GPR30) antagonist with a Ki of 20 nM.
M7353 Tamoxifen Tamoxifen is a estrogen receptor partial agonist/antagonist.
M4836 G-1 G-1 is a potent and selective GPR30 receptor agonist (Ki = 11 nM, EC50 = 2 nM).
M4374 Gypenoside-XVII Gypenoside XVII is a novel phytoestrogens belonging to gypenosides, which can activate estrogen receptors.
M4368 Kaempferol Kaempferol is an inverse agonist of ERRα and ERRγ that inhibits estrogen receptor (ER α) expression in breast cancer cells and induces apoptosis by activating MEK-MAPK in glioblastoma cells and lung cancer cells. It can be used in breast cancer research.
M3371 Estriol Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.
M2174 Calcitriol Calcitriol is an Active metabolite of vitamin D3 that activates the vitamin D receptor. *The compound is unstable in solutions, freshly prepared is recommended
M1966 Fulvestrant Fulvestrant is a Estrogen receptor (ER) antagonist with IC50 of 0.094 nM. Fulvestrant can also induce autophagy and apoptosis, and has anti-tumor effect.
M54736 hFSH-β-(33-53) TFA hFSH-β-(33-53) TFA, a thiol-containing peptide which corresponds to a second FSH receptor-binding domain, is a FSHR (follicle-stimulating hormone receptor) antagonist. hFSH-β-(33-53) TFA inhibits binding of FSH to receptor and is a partial agonist of estradiol synthesis in Sertoli cells.
M45333 FLTX1 FLTX1 is a fluorescent tamoxifen derivative that specifically labels intracellular tamoxifen binding sites (estrogen receptors) under permeabilizing and non-permeabilizing conditions. In addition, FLTX1 exhibits potent anti-estrogenic activity of Tamoxifen in breast cancer cells.FLTX1 lacks estrogenic agonism in the uterus.
M30946 (±)-Equol (±)-Equol is the racemate of equol. (±)-equol exhibits EC50s of 200 and 74 nM for human ERα and ERβ, respectively. Equol is a metabolite of the soy isoflavones, daidzin and daidzein.
M29599 Imlunestrant Imlunestrant (LY-3484356) is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC).
M28607 Enclomiphene Enclomiphene ((E)-Clomiphene) is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes.
M27811 Endoxifen (Z-isomer) Endoxifen Z-isomer is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα). Endoxifen inhibits hERG tail currents at 50 mV in a concentration-dependent manner with IC50 values of 1.6 μM.
M22417 Bazedoxifene Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer.
M22289 Endoxifen Endoxifen is the key active metabolite of Tamoxifen and an estrogen receptor (ER) modulator with high affinity and specificity for the estrogen receptor and inhibits aromatase activity.Endoxifen has been used in studies related to breast cancer, sclerofibroblastoma, and bipolar disorder.
M21213 Tibolone Tibolone is a synthetic anabolic steroid with estrogenic, androgenic and progestagenic activities.
M20777 GSK5182 GSK5182 is a 4-Hydroxytamoxifen analog and a highly potent, selective, orally active estrogen-related receptor gamma (ERRγ) inverse agonist with an IC50 value of 79 nM.GSK5182 does not interact with other nuclear receptors, including ERRα and ERα. In addition, GSK5182 inhibits proinflammatory cytokine-induced catabolic factors and increases ROS production in liver cancer cells. cytokine-induced catabolic factors and increased ROS production in hepatocellular carcinoma cells.
M14634 MPP dihydrochloride MPP dihydrochloride is a highly selective estrogen receptor alpha (ERα) antagonist. MPP dihydrochloride reduces the ratio of p-ERα/ERα.
M14633 Isocurcumenol Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC50 values of 99.1µg/mL and 178.2 µg/mL in DLA and KB cells, respectively.




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