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Tamoxifen

Cat. No. M7353
Tamoxifen Structure
Synonym:

ICI47699; Z-Tamoxifen; trans-Tamoxifen

Size Price Availability Quantity
200mg USD 95 In stock
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Quality Control
Biological Activity

Tamoxifen is a selective estrogen receptor modulator (SERM). Exhibits antiestrogenic effects in mammary tissue and estrogen-like effects in bone. Anticancer. Tamoxifen citrate (Cat.No. 0999) is also available.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 371.51
Formula C26H29NO
CAS Number 10540-29-1
Purity 99.74%
Solubility DMSO 30 mg/mL
Storage at -20°C
References

N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea hydrochloride: the first selective 5-HT1C receptor antagonist.
Forbes, et al. J Med Chem. 1993;36: 1104. PMID: 8478907.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tamoxifen, ICI47699; Z-Tamoxifen; trans-Tamoxifen supplier, Estrogen Receptor, inhibitors

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