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Tamoxifen

Cat. No. M7353
Tamoxifen Structure
Synonym:

ICI47699; Z-Tamoxifen; trans-Tamoxifen

Size Price Availability Quantity
200mg USD 27  USD30 In stock
500mg USD 54  USD60 In stock
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Quality Control
Biological Activity

Tamoxifen is a selective estrogen receptor modulator (SERM). Exhibits antiestrogenic effects in mammary tissue and estrogen-like effects in bone. Anticancer. Tamoxifen citrate (Cat.No. 0999) is also available.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 371.51
Formula C26H29NO
CAS Number 10540-29-1
Purity 99.46%
Solubility DMSO 30 mg/mL
Storage at -20°C
References

N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea hydrochloride: the first selective 5-HT1C receptor antagonist.
Forbes, et al. J Med Chem. 1993;36: 1104. PMID: 8478907.

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SAR439859 (Amcenestrant)

SAR439859 (Amcenestrant) is an orally active, nonsteroidal and selective degrader of estrogen receptor, it is also a potent antagonist of ER with EC50 of 0.2 nM for ERα degradation.

4-Hydroxytamoxifen

4-Hydroxytamoxifen is a selective estrogen receptor modulator.

Methylpiperidino pyrazole

Methylpiperidino pyrazole (MPP) is an agonist for estrogen receptor α and lacks any ligand functionality with estrogen receptor (ER)β.

Endoxifen E-isomer hydrochloride

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tamoxifen, ICI47699; Z-Tamoxifen; trans-Tamoxifen supplier, Estrogen Receptor, inhibitors

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