Estradiol (17β-estradiol) is a human sex hormone and steroid, and the primary female sex hormone. It can be used to construct animal models of chronic non-bacterial prostatitis.
Fertil Steril. 2023 May 12;S0015-0282(23)00241-8.
Gut dysbiosis-derived β-glucuronidase promotes the development of endometriosis
Estradiol purchased from AbMole
Molecules. 2023 Apr 7.
Study of the Sensing Kinetics of G Protein-Coupled Estrogen Receptor Sensors for Common Estrogens and Estrogen Analogs
Estradiol purchased from AbMole
Front Endocrinol (Lausanne). 2022 May 31;13:862789.
TMPRSS2 Expression and Activity Modulation by Sex-Related Hormones in Lung Calu-3 Cells: Impact on Gender-Specific SARS-CoV-2 Infection
Estradiol purchased from AbMole
Molecular Weight | 272.38 |
Formula | C18H24O2 |
CAS Number | 50-28-2 |
Solubility (25°C) | 44 mg/mL in DMSO |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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