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Estradiol

Cat. No. M5625
Estradiol Structure
Synonym:

β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol

Size Price Availability Quantity
500mg USD 40.5  USD45 In stock
1g USD 54  USD60 In stock
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Quality Control
Biological Activity

Estradiol (17β-estradiol) is a human sex hormone and steroid, and the primary female sex hormone.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 272.38
Formula C18H24O2
CAS Number 50-28-2
Purity 99.86%
Solubility 44 mg/mL in DMSO
Storage at -20°C
References

Estradiol Increases Microglial Response to Lipopolysaccharide in the Ventromedial Hypothalamus during the Peripubertal Sensitive Period in Female Mice
Amarylis Velez-Perez, et al. eNeuro. 2020 Jul 2;7(4):ENEURO.0505-19.2020. PMID: 32554430.

Effects of preovulatory estradiol on embryo survival and pregnancy establishment in beef cows.
Madsen CA, et al. Anim Reprod Sci. 2015 Jul;158:96-103. PMID: 26022231.

Methods for long-term 17β-estradiol administration to mice
E Ingberg, et al. Gen Comp Endocrinol. 2012 Jan 1;175(1):188-93. PMID: 22137913.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Estradiol, β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol supplier, Estrogen Receptor, inhibitors

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