Estradiol (17β-estradiol) is a human sex hormone and steroid, and the primary female sex hormone.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||44 mg/mL in DMSO|
Estradiol Increases Microglial Response to Lipopolysaccharide in the Ventromedial Hypothalamus during the Peripubertal Sensitive Period in Female Mice
Amarylis Velez-Perez, et al. eNeuro. 2020 Jul 2;7(4):ENEURO.0505-19.2020. PMID: 32554430.
Effects of preovulatory estradiol on embryo survival and pregnancy establishment in beef cows.
Madsen CA, et al. Anim Reprod Sci. 2015 Jul;158:96-103. PMID: 26022231.
Methods for long-term 17β-estradiol administration to mice
E Ingberg, et al. Gen Comp Endocrinol. 2012 Jan 1;175(1):188-93. PMID: 22137913.
|Related Estrogen Receptor Products|
27-Hydroxycholesterol is a selective estrogen receptor modulator, and it is also an agonist of the liver X receptor.
SAR439859 (Amcenestrant) is an orally active, nonsteroidal and selective degrader of estrogen receptor, it is also a potent antagonist of ER with EC50 of 0.2 nM for ERα degradation.
4-Hydroxytamoxifen is a selective estrogen receptor modulator.
Methylpiperidino pyrazole (MPP) is an agonist for estrogen receptor α and lacks any ligand functionality with estrogen receptor (ER)β.
|Endoxifen E-isomer hydrochloride
Endoxifen E-isomer hydrochloride is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM).
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