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27-Hydroxycholesterol

Cat. No. M10348
27-Hydroxycholesterol Structure
Size Price Availability Quantity
2mg USD 90  USD100 In stock
5mg USD 207  USD230 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

27-Hydroxycholesterol is a selective estrogen receptor modulator, and it is also an agonist of the liver X receptor. 27-Hydroxycholesterol significantly increases cell proliferation of LNCaP and PC3 cells and this effect can be attenuated by estrogen receptor inhibitors. 27-Hydroxycholesterol is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27-Hydroxycholesterol also acts as an endogenous selective estrogen receptor modulator capable of increasing breast cancer growth and metastasis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 402.65
Formula C27H46O2
CAS Number 20380-11-4
Purity >98%
Solubility Ethanol 10 mg/mL
Storage at -20°C
References

The cholesterol metabolite 27-hydroxycholesterol stimulates cell proliferation via ERβ in prostate cancer cells
Shaneabbas Raza, et al. Cancer Cell Int. 2017 May 11;17:52. PMID: 28503095.

Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer
Siker Kimbung, et al. Endocr Relat Cancer. 2017 Jul;24(7):339-349. PMID: 28442559.

27-hydroxycholesterol is an endogenous selective estrogen receptor modulator
Carolyn D DuSell, et al. Mol Endocrinol. 2008 Jan;22(1):65-77. PMID: 17872378.

27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells
X Fu, et al. J Biol Chem. 2001 Oct 19;276(42):38378-87. PMID: 11504730.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 27-Hydroxycholesterol supplier, Estrogen Receptor, inhibitors

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