Free shipping on all orders over $ 500


Cat. No. M2174
Calcitriol Structure

1,25-Dihydroxyvitamin D3

Size Price Availability Quantity
2mg USD 90  USD100 In stock
5mg USD 211.5  USD235 In stock
10mg USD 427.5  USD475 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Calcitriol is an Active metabolite of vitamin D3 that activates the vitamin D receptor. Calcitriol (also called 1,25-dihydroxyvitamin D3) is synthesized from 7-dehydrocholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Calcitriol also inhibits the release of calcitonin, a hormone which reduces blood calcium primarily by inhibiting calcium release from bone. Calcitriol inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells. Calcitriol increases blood calcium levels ( [Ca2+] ) by promoting absorption of dietary calcium from the gastrointestinal tract and increasing renal tubular reabsorption of calcium thus reducing the loss of calcium in the urine. Calcitriol also stimulates release of calcium from bone by its action on the specific type of bone cells referred to as osteoblasts, causing them to release RANKL, which in turn activates osteoclasts.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 416.64
Formula C27H44O3
CAS Number 32222-06-3
Purity 98.41%
Solubility DMSO 56 mg/mL
Storage -20°C, protect from light, dry, sealed

Calcitriol in cancer treatment: from the lab to the clinic.
Beer TM, et al. Mol Cancer Ther. 2004 Mar;3(3):373-81. PMID: 15026558.

The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis.
Canalejo A, et al. J Am Soc Nephrol. 2000 Oct;11(10):1865-72. PMID: 11004217.

Related Estrogen Receptor Products

27-Hydroxycholesterol is a selective estrogen receptor modulator, and it is also an agonist of the liver X receptor.

SAR439859 (Amcenestrant)

SAR439859 (Amcenestrant) is an orally active, nonsteroidal and selective degrader of estrogen receptor, it is also a potent antagonist of ER with EC50 of 0.2 nM for ERα degradation.


4-Hydroxytamoxifen is a selective estrogen receptor modulator.

Methylpiperidino pyrazole

Methylpiperidino pyrazole (MPP) is an agonist for estrogen receptor α and lacks any ligand functionality with estrogen receptor (ER)β.

Endoxifen E-isomer hydrochloride

Endoxifen E-isomer hydrochloride is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM).

Abmole Inhibitor Catalog 2017

Keywords: Calcitriol, 1,25-Dihydroxyvitamin D3 supplier, Estrogen Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.