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Bay 11-7082

Cat. No. M2040

Bay 11-7082 Structure

Synonym: Bay 11-7821

Size Price Availability Quantity
25mg USD 120 In stock
50mg USD 200 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Bay 11-7082 (Bay 11-7821) is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation. Bay 11-7082 selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation. Bay 11-7082 inhibits the TNF-α-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells with IC50 values of 5-10 µM. Bay 11-7082 also reversibly activates MAP kinases and stimulates apoptosis. Bay 11-7082 rapidly and efficiently reduced the DNA binding of NF-kappaB in HTLV-I-infected T-cell lines and down-regulated the expression of the antiapoptotic gene, Bcl-x(L), regulated by NF-kappaB, whereas it had little effect on the DNA binding of another transcription factor, AP-1. Furthermore, Bay 11-7082- induced apoptosis of primary ATL cells was more prominent than that of normal peripheral blood mononuclear cells, and apoptosis of these cells was also associated with down-regulation of NF-kappaB activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 207.25
Formula C10H9NO2S
CAS Number 19542-67-7
Purity >99%
Solubility DMSO >20 mg/mL
Storage at -20°C
References

The role of Rac1 in the regulation of NF-κB activity, cell proliferation, and cell migration in non-small cell lung carcinoma.
Gastonguay A, et al. Cancer Biol Ther. 2012 Jun;13(8):647-56. PMID: 22549160.

The inhibitor of I kappa B alpha phosphorylation BAY 11-7082 prevents NMDA neurotoxicity in mouse hippocampal slices.
Goffi F, et al. Neurosci Lett. 2005 Apr 4;377(3):147-51. PMID: 15755516.

Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells.
Mori N, et al. Blood. 2002 Sep 1;100(5):1828-34. PMID: 12176906.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Bay 11-7082, Bay 11-7821 supplier, IκB/IKK, inhibitors

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