Polyethylene glycol 8000 (PEG 8000) is a polymer formed by condensation reaction of ethylene oxide and water. Polyethylene glycol is used for the isolation of plasmid DNA and the precipitation of phage. When exposed to air, PEG is susceptible to oxidative degradation. PEG does not hydrolyze or deteriorate during storage. PEG does not support mold growth.
Cell Death Differ. 2022 Jul;29(7):1395-1408.
SARS-CoV-2 membrane protein causes the mitochondrial apoptosis and pulmonary edema via targeting BOK
PEG8000 purchased from AbMole
Virol Sin. 2022 Aug 16;S1995-820X(22)00143-2.
CK1α upregulates the IFNAR1 expression to prompt the anti-HBV effect of type I IFN in hepatoma carcinoma cells
PEG8000 purchased from AbMole
J Nanobiotechnology. 2021 Nov 25;19(1):391.
Nanovesicles derived from bispecific CAR-T cells targeting the spike protein of SARS-CoV-2 for treating COVID-19
PEG8000 purchased from AbMole
| Formula | HO(CH2CH2O)nH |
| CAS Number | 25322-68-3 |
| Solubility (25°C) | Soluble in Water |
| Storage | 18~25°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Solvents & Excipients Products |
|---|
| Dimethyl sulfoxide
Dimethyl sulfoxide (DMSO) is a commonly used organic solvent with high solvency capacity, soluble in most organic substances such as water, ethanol, propanol, ether, benzene and chloroform, and can be used for the dissolution of compounds and other products. |
| ATX-002
ATX-002 is an ionizable cationic lipid for RNA drug delivery with theoretical pKa (c-pKa) and measured pKa values of 8.68 and 6.03, respectively. |
| 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE is a phospholipid that can be used in studies related to drug delivery. |
| PEG1500
PEG1500 is a polymer produced by the condensation reaction of ethylene oxide and water, generally white waxy solid in appearance, often used as a pharmaceutical excipient. |
| PLGA lactide:glycolide (50:50) (MW 90000)
PLGA lactide:glycolide (50:50) (MW 90000) Poly(D,L-propylidene-CO-ethylidene glycolide) is a synthetic amino acid that can be used for macromolecular delivery. |
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