Dithiothreitol (DTT) is a redox reagent commonly used as a reducing agent for thiolated DNA. Dithiothreitol (DTT) is also used to reduce the disulfide bonds of proteins.
Cell Res. 2023 Jun;33(6):464-478.
SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches
DTT purchased from AbMole
Nucleic Acids Res. 2022 Aug 12;50(14):7938-7958.
HDAC1 and PRC2 mediate combinatorial control in SPI1/PU.1-dependent gene repression in murine erythroleukaemia
DTT purchased from AbMole
Nat Commun. 2020 Dec 22;11(1):6438.
MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression
DTT purchased from AbMole
J Virol. 2020 Feb 14;94(5):e01791-19.
Targeting Kaposi's Sarcoma-Associated Herpesvirus ORF21 Tyrosine Kinase and Viral Lytic Reactivation by Tyrosine Kinase Inhibitors Approved for Clinical Use
DTT purchased from AbMole
Exp Cell Res. 2020 Nov 1;396(1):112237.
LRTM1 promotes the differentiation of myoblast cells by negatively regulating the FGFR1 signaling pathway
DTT purchased from AbMole
| Molecular Weight | 154.25 |
| Formula | C4H10O2S2 |
| CAS Number | 3483-12-3 |
| Solubility (25°C) | DMSO: ≥ 75 mg/mL Water: ≥ 90 mg/mL |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Yiwen Wang, et al. Toxicity of Dithiothreitol (DTT) to Drosophila melanogaster
[4] Brittany C Hudson, et al. The effects of dithiothreitol (DTT) on fluorescent qPCR dyes
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