Free shipping on all orders over $ 500

PD1-PDL1 inhibitor 1

Cat. No. M8959
PD1-PDL1 inhibitor 1 Structure
Synonym:

PD-1/PD-L1 inhibitor 1

Size Price Availability Quantity
10mg USD 215 In stock
25mg USD 425 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

PD1-PDL1 inhibitor 1 is an inhibitor of the PD-1 /PD-Ll protein/protein interaction with IC50 value of 6 nM. PD1-PDL1 inhibitor is also an immunomodulator. PD-L1 also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. It appears that upregulation of PD-L1 may allow cancers to evade the host immune system.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 475.58
Formula C29H33NO5
CAS Number 1675201-83-8
Purity >99%
Solubility DMSO: ≥ 60 mg/mL
Storage at -20°C
References

The future of immunotherapy for sarcoma.
Tsukahara T, et al. Expert Opin Biol Ther. 2016 Aug;16(8):1049-57. PMID: 27158940.

Co-inhibition of colony stimulating factor-1 receptor and BRAF oncogene in mouse models of BRAFV600E melanoma.
Ngiow SF, et al. Oncoimmunology. 2015 Dec 10;5(3):e1089381. PMID: 27141346.

Reversal of in situ T-cell exhaustion during effective human antileukemia responses to donor lymphocyte infusion.
Bachireddy P, et al. Blood. 2014 Feb 27;123(9):1412-21. PMID: 24357730.

Related PD-1/PD-L1 Products
Pembrolizumab

Pembrolizumab is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities. MW : 146.286 KD.

Atezolizumab

Atezolizumab is a fully humanized, IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1, but not the interaction of PD-L2 with PD-1. MW : 145 KD.

Nivolumab

Nivolumab is a genetically engineered, fully human immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1,PCD-1) with immune checkpoint inhibitory and antineoplastic activities. MW : 143.597 KD.

BMS202

BMS202 (PD-1/PD-L1 inhibitor 2) is a inhibitor of the PD-1 (Programmed death- 1) /PD-L1 (Programmed death-ligand 1) protein/protein interaction with IC50 value of 18 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PD1-PDL1 inhibitor 1, PD-1/PD-L1 inhibitor 1 supplier, PD-1/PD-L1, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.