BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1) is an inhibitor of PD-1/PD-L1 protein/protein interaction with an IC50 of 6 to 100 nM.
Cell Death Discov. 2023 Jun 30;9(1):205.
RNF8 enhances the sensitivity of PD-L1 inhibitor against melanoma through ubiquitination of galectin-3 in stroma
BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1) purchased from AbMole
J Cancer Res Clin Oncol. 2023 Feb 6.
Carbon ion irradiation induces DNA damage in melanoma and optimizes the tumor microenvironment based on the cGAS–STING pathway
BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1) purchased from AbMole
J Allergy Clin Immunol. 2020 Mar;145(3):855-867.e8.
Effects of myeloid and plasmacytoid dendritic cells on ILC2s in patients with allergic rhinitis.
BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1) purchased from AbMole
| Molecular Weight | 475.58 |
| Formula | C29H33NO5 |
| CAS Number | 1675201-83-8 |
| Solubility (25°C) | DMSO: ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Tsukahara T, et al. Expert Opin Biol Ther. The future of immunotherapy for sarcoma.
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