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PD1-PDL1 inhibitor 1

Cat. No. M8959
PD1-PDL1 inhibitor 1 Structure
Synonym:

PD-1/PD-L1 inhibitor 1

Size Price Availability Quantity
5mg USD 118.8  USD132 In stock
10mg USD 189  USD210 In stock
25mg USD 378  USD420 In stock
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Quality Control
Biological Activity

PD1-PDL1 inhibitor 1 is an inhibitor of the PD-1 /PD-Ll protein/protein interaction with IC50 value of 6 nM. PD1-PDL1 inhibitor is also an immunomodulator. PD-L1 also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. It appears that upregulation of PD-L1 may allow cancers to evade the host immune system.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 475.58
Formula C29H33NO5
CAS Number 1675201-83-8
Purity 99.57%
Solubility DMSO: ≥ 60 mg/mL
Storage at -20°C
References

Inhibition of programmed death-1 decreases neointimal hyperplasia after patch angioplasty
Hualong Bai, et al. J Biomed Mater Res B Appl Biomater. 2021 Feb;109(2):269-278. PMID: 32770622.

The future of immunotherapy for sarcoma.
Tsukahara T, et al. Expert Opin Biol Ther. 2016 Aug;16(8):1049-57. PMID: 27158940.

Co-inhibition of colony stimulating factor-1 receptor and BRAF oncogene in mouse models of BRAFV600E melanoma.
Ngiow SF, et al. Oncoimmunology. 2015 Dec 10;5(3):e1089381. PMID: 27141346.

Reversal of in situ T-cell exhaustion during effective human antileukemia responses to donor lymphocyte infusion.
Bachireddy P, et al. Blood. 2014 Feb 27;123(9):1412-21. PMID: 24357730.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PD1-PDL1 inhibitor 1, PD-1/PD-L1 inhibitor 1 supplier, PD-1/PD-L1, inhibitors

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