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Cat. No. M9267
Coelenterazine Structure

Oplophorus; luciferin; CLZN

Size Price Availability Quantity
2mg USD 237 In stock
5mg USD 367 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Coelenterazine (CTZ) can be catalyzed by luciferases, such as the sea pansy Renilla reniformis (Rluc) and the marine copepod Gaussia princeps (Gluc), which results in emission of blue light. In Gli36-Gluc- or Gli36-Rluc-expressing Gli36 cells, coelenterazine (8 μM/ml) shows a bioluminescence signal. 

In vivo, in 4T1-implanted mouse, Coelenterazine detects cancer-associated superoxide anion and used to evaluate the role of superoxide anion in cancer cell biology and its role in pathology.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 423.46
Formula C26H21N3O3
CAS Number 55779-48-1
Purity >98%
Solubility DMSO: ≥ 40 mg/mL
Storage -20°C, protect from light

Multimodality Imaging of Cancer Superoxide Anion Using the Small Molecule Coelenterazine.
Bronsart LL, et al. Mol Imaging Biol. 2016 Apr;18(2):166-71. PMID: 26420297.

A water-soluble coelenterazine for sensitive in vivo imaging of coelenterate luciferases.
Morse D, et al. Mol Ther. 2012 Apr;20(4):692-3. PMID: 22472977.

Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine.
Pichler A, et al. Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1702-7. PMID: 14755051.

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Keywords: Coelenterazine, Oplophorus; luciferin; CLZN supplier, inhibitors

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