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DAPI dihydrochloride

Cat. No. M5106
DAPI dihydrochloride Structure
Synonym:

4',6-Diamidino-2-phenylindole dihydrochloride

Size Price Availability Quantity
5mg USD 40.5  USD45 In stock
10mg USD 54  USD60 In stock
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Quality Control
Biological Activity

DAPI dihydrochloride is a fluorescent stain by binding in the minor grove of A-T rich sequences of DNA.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 350.25
Formula C16H17Cl2N5
CAS Number 28718-90-3
Purity >98%
Solubility Water 5 mg/mL (Need ultrasonic)
Storage -20°C, protect from light, sealed
References

LncRNA HOXA-AS2 Activates the Notch Pathway to Promote Cervical Cancer Cell Proliferation and Migration
Qunxiong Wu, et al. Reprod Sci. 2021 Jun 2. PMID: 34076871.

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Keywords: DAPI dihydrochloride, 4',6-Diamidino-2-phenylindole dihydrochloride supplier, Fluorescent Dye, inhibitors

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