Free shipping on all orders over $ 500

Carboplatin

Cat. No. M2288
Carboplatin Structure
Synonym:

Paraplatin

Size Price Availability Quantity
100mg USD 60 In stock
200mg USD 100 In stock
500mg USD 180 In stock
1g USD 300 In stock
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Carboplatin is a second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. Carboplatin possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. Carboplatin is used against some forms of cancer (mainly ovarian carcinoma, lung, head and neck cancers).

Protocol
Cell Experiment
Cell lines 5637 cells
Preparation method Cells were dosed and incubated with 290 μM carboplatin or 290 μM carboplatin combined with 0.08 μM paclitaxel for 4 h, each including 0.43 μM[14C]carboplatin (106 dpm/ml). After washing, cells were maintained with 14C carboplatin-free culture media. DNA was extracted from cells and converted to graphite and measured by AMS for 14C quantification as previously described.
Concentrations 290 μM
Incubation time 4 h
Animal Experiment
Animal models Female 6‐week‐old nude mice
Formulation
Dosages 100 mg/kg
Administration s.c.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 371.25
Formula C6H12N2O4Pt
CAS Number 41575-94-4
Purity >99%
Solubility DMSO
Storage at -20°C
References

Paclitaxel Enhances Carboplatin-DNA Adduct Formation and Cytotoxicity.
Jiang S, et al. Chem Res Toxicol. 2015 Dec 21;28(12):2250-2. PMID: 26544157.

Enhancement of paclitaxel and carboplatin therapies by CCL2 blockade in ovarian cancers.
Moisan F, et al. Mol Oncol. 2014 Oct;8(7):1231-9. PMID: 24816187.

Related DNA/RNA Synthesis Products
Vidarabine

Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.

Uridine

Uridine is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.

Rifampicin

Rifampin is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.

Mitomycin C

Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers.

Mercaptopurine (6-MP)

Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Carboplatin, Paraplatin supplier, DNA/RNA Synthesis, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.