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Stattic

Cat. No. M3032
Stattic Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
25mg USD 90 In stock
50mg USD 140 In stock
100mg USD 220 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1.

Protocol
Cell Experiment
Cell lines Ly3 cells
Preparation method MTS
Concentrations ~2.5 μM
Incubation time 48 h
Animal Experiment
Animal models Ly3 parental NOD/SCID IL2R null xenograft
Formulation
Dosages 3.75 mg/kg every day
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 211.19
Formula C8H5NO4S
CAS Number 19983-44-9
Purity >98%
Solubility DMSO 30 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Stattic supplier, STAT, inhibitors

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