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Stattic

Cat. No. M3032
Stattic Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 40  USD50 In stock
10mg USD 44  USD55 In stock
25mg USD 72  USD90 In stock
50mg USD 112  USD140 In stock
100mg USD 176  USD220 In stock
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Quality Control
Biological Activity

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1.

Product Citations
Protocol
Cell Experiment
Cell lines Ly3 cells
Preparation method MTS
Concentrations ~2.5 μM
Incubation time 48 h
Animal Experiment
Animal models Ly3 parental NOD/SCID IL2R null xenograft
Formulation
Dosages 3.75 mg/kg every day
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 211.19
Formula C8H5NO4S
CAS Number 19983-44-9
Purity 98.94%
Solubility DMSO 30 mg/mL
Storage at -20°C
References

[1] Dipak K Poria, et al. The STAT3 inhibitor Stattic acts independently of STAT3 to decrease histone acetylation and modulate gene expression

[2] Sijia Li, et al. Stattic alleviates acute hepatic damage induced by LPS/d-galactosamine in mice

[3] Sevda Jafari, et al. STAT3 inhibitory stattic enhances immunogenic cell death induced by chemotherapy in cancer cells

[4] Chang-Hong Li, et al. Stattic inhibits RANKL-mediated osteoclastogenesis by suppressing activation of STAT3 and NF-κB pathways

[5] Jochen Schust, et al. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

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Keywords: Stattic supplier, STAT, inhibitors

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