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Acetylcysteine

Cat. No. M5385

Acetylcysteine Structure
Size Price Availability Quantity
100mg USD 80 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 163.19
Formula C5H9NO3S
CAS Number 616-91-1
Purity >99%
Solubility 33 mg/mL in DMSO
Storage at -20°C
References

Acetylcysteine for treatment of autism spectrum disorder symptoms.
Stutzman D, et al. Am J Health Syst Pharm. 2015 Nov 15;72(22):1956-9. PMID: 26541950.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Acetylcysteine supplier, TNF-alpha, inhibitors

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