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Acetylcysteine (NAC)

Cat. No. M5385
Acetylcysteine (NAC) Structure
Synonym:

N-Acetyl-L-cysteine; LNAC; NAC

Size Price Availability Quantity
Free Sample (1-2 mg)  USD 0 In stock
500mg USD 27  USD30 In stock
1g USD 36  USD40 In stock
5g USD 45  USD50 In stock
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Quality Control
Biological Activity

Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor.

Product Citations
Customer Product Validations & Biological Datas
Source Pathogens 2020 Aug. Figure 5. N-acetyl-l-cysteine (Abmole Bioscience Inc, Houston, TX, USA)
Method Cell Viability Assay
Cell Lines Caco-2 cells
Concentrations 10 mM/well
Incubation Time 6 h
Results It was shown in Figure 5A that pre-incubation of Caco-2 cells with NAC for 3 h before exposure to trophozoites could block the release of Cyt-c. The activation of CASP3 was diminished by NAC in trophozoites-treated cells
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 163.19
Formula C5H9NO3S
CAS Number 616-91-1
Purity 100.0%
Solubility DMSO 30 mg/mL
Water 30 mg/mL
Storage at -20°C
References

Artemisinin Derivatives Inhibit Non-small Cell Lung Cancer Cells Through Induction of ROS-dependent Apoptosis/Ferroptosis
Qiuting Zhang, et al. J Cancer. 2021 May 13;12(13):4075-4085. PMID: 34093811.

Acetylcysteine for treatment of autism spectrum disorder symptoms.
Stutzman D, et al. Am J Health Syst Pharm. 2015 Nov 15;72(22):1956-9. PMID: 26541950.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Acetylcysteine (NAC), N-Acetyl-L-cysteine; LNAC; NAC supplier, ROS, inhibitors

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