CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM.
*The compound is unstable in solutions, freshly prepared is recommended
Int Immunopharmacol. 2024 Feb;129:111637.
Fraxin (7-hydroxy-6-methoxycoumarin 8-glucoside) confers protection against ionizing radiation-induced intestinal epithelial injury in vitro and in vivo
CH-223191 purchased from AbMole
Cell Death Dis. 2023 Feb 8;14(2):92.
Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury
CH-223191 purchased from AbMole
J Immunol. 2023 Nov 29;ji2300090.
The Microbial Tryptophan Metabolite Contributes to the Remission of Salmonella typhimurium Infection in Mice
CH-223191 purchased from AbMole
Chemosphere. 2022 Nov;307(Pt 2):135962.
Fine particulate matter induces heart defects via AHR/ROS-mediated endoplasmic reticulum stress
CH-223191 purchased from AbMole
Advances in Clinical Medicine. 13(3), 4166-4175.
The Regulation of Aryl Hydrocarbon Receptor (AhR) in Dry Eye
CH-223191 purchased from AbMole
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Animal models | Male ICR mice (6 weeks old) |
Formulation | 10 mg/kg in corn oil |
Dosages | 10 mg/kg once a day for 25 days |
Administration | oral |
Molecular Weight | 333.39 |
Formula | C19H19N5O |
CAS Number | 301326-22-7 |
Solubility (25°C) | DMSO ≥ 30 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Kuo-Liang Wei, et al. Sorafenib is an antagonist of the aryl hydrocarbon receptor
[5] Lizath M Aguiniga, et al. Acyloxyacyl hydrolase regulates voiding activity
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