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PDTC

Cat. No. M4005

PDTC Structure

Synonym: Ammonium pyrrolidinedithiocarbamate

Size Price Availability Quantity
100mg USD 65 In stock
500mg USD 110 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

PDTC can enhance the cell apoptosis induced by TNF-α, which may be associated with the blocking of TNF-α-activated NF-κB signaling pathway by PDTC, the down-regulation of survivin expression, and up-regulation of caspase-3 expression.in NMSC PDTC acts as pro-oxidant and enhances IR-induced cell cytotoxicity by increasing H(2)O(2)formation and thiol oxidation.PDTC and MG132, inhibitors of NF-kappaB, block ET-induced vasodilation in isolated rat skeletal muscle arterioles.PDTC has effects at both the level of the aortic segment as well as the resistance arteriole.PDTC prevents induction of nitric oxide synthase (NOS) by inhibiting translation of NOS mRNA.PDTC induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 164.28
Formula C5H9NS2·NH3
CAS Number 5108-96-3
Purity >99%
Solubility DMSO 15mg/ml
Storage at -20°C
Customer Product Validations & Biological Datas
Source Vete Mic (2017). Figure 4. PDTC (Abmole Bioscience, Houston, TX, USA)
Method Treatment by inhibitors
Cell Lines DCs
Concentrations 20 µM
Incubation Time 48 h
Results The PDTC (NF-kB inhibitor) treatment significantly decreased the MHC II, CD80, CD86, CD40 expressions. As to cytokine production (Fig. 4e–h), both inhibitors significantly restrained TNF-a, IFN-g and IL-6 secretions, with a minimal effect on IL-12p70.
Rating
Product Citations
References

[NF-κb inhibitor PDTC enhances tumor necrosis factor α-induced apoptosis of gastric cancer cell SGC-7901].
Cao MZ, et al. Zhonghua Wei Chang Wai Ke Za Zhi. 2013 Jun;16(6):578-82. PMID: 23801215.

Pyrrolidine dithiocarbamate (PDTC) blocks apoptosis and promotes ionizing radiation-induced necrosis of freshly-isolated normal mouse spleen cells.
Thompson JS, et al. Apoptosis. 2010 Jun;15(6):705-14. PMID: 20333468.

PDTC and Mg132, inhibitors of NF-kappaB, block endotoxin induced vasodilation of isolated rat skeletal muscle arterioles.
Snyder JG, et al. Shock. 2002 Apr;17(4):304-7. PMID: 11954831.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: PDTC, Ammonium pyrrolidinedithiocarbamate supplier, NF-κB, inhibitors

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