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SBE-β-CD (Sulfobutylether beta-cyclodextrin)

Cat. No. M4837
SBE-β-CD (Sulfobutylether beta-cyclodextrin) Structure
Synonym:

Sulfobutylether-β-Cyclodextrin

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Free Sample (0.5-1 mg)  USD 0 In stock
500mg USD 50  USD50 In stock
1g USD 90  USD90 In stock
5g USD 190  USD190 In stock
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Quality Control & Documentation
Biological Activity

SBE-β-CD (Sulfobutylether beta-cyclodextrin) is a unique reproducible mixture of polyanionic β-cyclodextrin derivatives in which a sodium sulfonate salt is tethered to the lipophilic cyclodextrin cavity by a butyl ether group, or sulfobutylether (SBE). The sulfobutyl ether (SBE) substituent is introduced at the 2, 3, and 6 positions in one or more of the glucopyranose units in the cyclodextrin structure. 

Product Citations
Customer Product Validations & Biological Datas
Source J Biomed Mater Res B Appl Biomater (2016). Figure 3. Captisol
Method Transmission electron microscopy
Cell Lines MRC-5 cells
Concentrations 1 μM
Incubation Time 24 h
Results Deionized water-dispersed ICG, SCyD, and MCyD showed a size distribution ranging from 2 to 200 nm.
Source J Biomed Mater Res B Appl Biomater (2016). Figure 1. Captisol
Method Fluorescence
Cell Lines
Concentrations 10 mM
Incubation Time 24 h
Results Over 24 h, ICG retained just 0.383 of its initial fluorescence in water, while MCyD-I and SCyD-I in water retained 1.943 and 2.063 higher fluorescence than ICG at t0. In PBS, ICG retained 0.753 of its initial fluorescence while MCyD-I actually increased to 29.863 and SCyD-I retained 20.833 of initial ICG fluorescence in PBS.
Protocol (for reference only)
Cell Experiment
Cell lines Caco-2 cells
Preparation method The cells were then preincubated for 30 min without Nos solution+permeation enhancer CH or CP and then incubated for 120 min at 37 ℃ with the Nos solution (50 mg/ml)+permeation enhancer CH or CP.
Concentrations 50 mg/ml
Incubation time 2 h
Animal Experiment
Animal models pig
Formulation 10-mL solution composed of 25% water and 75% PEG400
Dosages 5 mg/kg
Administration bolus infusions
Chemical Information
Molecular Weight 1451.29
Formula C50H84Na2O41S2
CAS Number 182410-00-0
Solubility (25°C) Water > 120 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mamoru Fukuda, et al. Int J Pharm. Influence of sulfobutyl ether beta-cyclodextrin (Captisol) on the dissolution properties of a poorly soluble drug from extrudates prepared by hot-melt extrusion

[2] Valentino J Stella, et al. Sulfobutylether-β-cyclodextrin

[3] Farouk Semcheddine, et al. Effects of the Preparation Method on the Formation of True Nimodipine SBE-β-CD/HP-β-CD Inclusion Complexes and Their Dissolution Rates Enhancement

[4] David R Luke, et al. Review of the basic and clinical pharmacology of sulfobutylether-beta-cyclodextrin (SBECD)

[5] Valentino J Stella, et al. Cyclodextrins

[6] V Zia, et al. Effect of cyclodextrin charge on complexation of neutral and charged substrates: comparison of (SBE)7M-beta-CD to HP-beta-CD

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Keywords: SBE-β-CD (Sulfobutylether beta-cyclodextrin), Sulfobutylether-β-Cyclodextrin supplier, Solvents & Excipients, inhibitors, activators


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