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Indomethacin

Cat. No. M3466
Indomethacin Structure
Synonym:

Indometacin

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 35  USD35 In stock
500mg USD 50  USD50 In stock
1g USD 70  USD70 In stock
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Quality Control & Documentation
Biological Activity

Indomethacin (Indocid, Indocin) is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling. Indomethacin works by inhibiting the production of prostaglandins, molecules known to cause these symptoms. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. Indomethacin inhibits lipopolysaccharide (LPS)-induced PGE2 production (COX-2) in a human whole blood assay with a potency (IC50=0.68±0.17 μM), and suppresses coagulation-induced TXB2 production (COX-1) (IC50=0.19±0.02 μM). Indomethacin blocks COX-1 with an IC50 of 20±1 nM in U937 cell microsomes at a low arachidonic acid concentration (0.1 μM).

Product Citations
Chemical Information
Molecular Weight 357.79
Formula C19H16ClNO4
CAS Number 53-86-1
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] D Riendeau, et al. Br J Pharmacol. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor

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Keywords: Indomethacin, Indometacin supplier, Animal Modeling, inhibitors, activators


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