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Cat. No. M1748
LBH589 Structure

NVP-LBH589, Panobinostat

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 50 In stock
50mg USD 130 In stock
200mg USD 300 In stock
500mg USD 460 In stock
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Quality Control
Biological Activity

LBH589 (Panobinostat, NVP-LBH589) is a novel deacetylase inhibitor and has been shown to induce acetylation of histone H3 and H4, increase p21 levels, disrupt the chaperone function of hsp90, and induce cell-cycle G1 phase accumulation and apoptosis of K562 cells and acute leukemia MV4-11 cells. LBH589 (Panobinostat, NVP-LBH589) has also recently been found to significantly increase in vitro the survival of motor neuron (SMN) protein levels in cells of patients suffering from spinal muscular atrophy.

Customer Product Validations & Biological Datas
Source PLoS One (2015). Figure 2. LBH589
Method Apoptosis assay
Cell Lines SK-NEP-1 and G401 cells
Concentrations 50 nM
Incubation Time 24 h
Results The result showed that among cells treated with LBH589 50nM and 100nM for 24 hours, many more cells showed apoptotic feature compared with control group, for both SK-NEP-1 and G401 cells
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 349.43
Formula C21H23N3O2
CAS Number 404950-80-7
Purity 100.0%
Solubility DMSO
Storage at -20°C

ING1 and 5-Azacytidine Act Synergistically to Block Breast Cancer Cell Growth.
Thakur et al. PLoS One. 2012;7(8):e43671. PMID: 22916295.

The prostate cancer blocking potential of the histone deacetylase inhibitor LBH589 is not enhanced by the multi receptor tyrosine kinase inhibitor TKI258.
Vallo et al. Invest New Drugs. 2012 Jul 17. PMID: 22801803.

LBH589 Enhances T Cell Activation In Vivo and Accelerates Graft-versus-Host Disease in Mice.
Wang et al. Biol Blood Marrow Transplant. 2012 Aug;18(8):1182-1190. PMID: 22698484.

HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA).
Mehdi et al. Pancreatology. 2012 Mar;12(2):146-55. PMID: 22487525.

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Abmole Inhibitor Catalog 2017

Keywords: LBH589, NVP-LBH589, Panobinostat supplier, HDAC, inhibitors

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