Catalog

HDAC Histone deacetylases

Inhibitors

Cat.No.	Name	Information
M5259	Citarinostat	Citarinostat (ACY-241) is an orally available selective HDAC6 inhibitor with IC50 of 2.6 nM and 46 nM for HDAC6 and HDAC3, respectively. It has 13 to 18-fold selectivity towards HDAC6 in comparison to HDAC1-3.
M5200	BRD73954	BRD73954 ia a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.
M5152	Sodium Butyrate	Sodium butyrate is the sodium salt of butyric acid, which has been reported to cause hyperacetylation of histones due to its role as a HDAC inhibitor with IC50 values of 0.3, 0.4, 0.3 mM for HDAC1, 2 and 7 respectively.
M4986	LMK-235	LMK235 is a HDAC inhibitor, previously shown to be a novel and specific inhibitor of human HDAC4 and 5, with IC50 values of 0.49 μM (A2780) and 0.32 μM (A2780 CisR).
M4868	4SC-202	4SC-202 is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1).
M3988	Sulforaphane	Sulforaphane (SFN) extracted from broccoli sprout is an agent with potent anti-oxidant and anti-inflammatory activity.
M3979	Caffeic acid	Caffeic acid is an endogenous phenolic phytochemical compound that exists in plants and many foods.
M3931	RGFP966	RGFP966 is a specific inhibitor of HDAC3 with an IC50 value of 0.08 μM and no effective inhibition of any other HDAC at concentrations up to 15 μM.
M3888	CAY10603	CAY10603 is a potent and selective inhibitor of HDAC6 with IC50 of 2 pM.
M3643	TMP269	TMP269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.
M3405	AR-42	AR-42 is an HDAC inhibitor with IC50 of 30 nM.
M3395	M344	M344 is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation.
M3243	Pyroxamide	Pyroxamide (NSC 696085) is a potent, affinity-purified HDAC1 inhibitor with ID50 of 100 nM.
M3095	Tubastatin A	Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
M3022	Sodium Phenylbutyrate	Sodium Phenylbutyrate is a transcriptional regulators that act by altering chromatin structure via the modulation of HDAC activity.
M3002	Scriptaid	Scriptaid is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3.
M2977	RGFP966	RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC.
M2975	RG2833	RG2833 (RGFP109) is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.
M2878	Nexturastat A	Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM, >190-fold selectivity over other HDACs.
M2400	Apicidin	Apicidin is a potent nonselective HDAC inhibitor with IC50 of 0.7 nM.
M2236	CI-994	CI-994 (N-acetyl dinaline, PD 123654) is a novel orally active HDAC inhibitor with IC50 of 0.57 μM for HDAC1.
M2123	Rocilinostat	Rocilinostat (ACY-1215) is an HDAC6-selective inhibitor with IC50 of 5 nM.
M2119	JNJ-26481585	JNJ-26481585 (Quisinostat) is a novel second-generation class I HDAC inhibitor.
M2111	CUDC-907	CUDC-907 is a potent, orally-available small molecule dual PI3K and HDAC inhibitor.
M2101	PCI-34051	PCI-34051 is a potent histone deacetylase (HDAC) 8 inhibitor with IC50 of 0.01 μM.
M2095	Resminostat	Resminostat is a potent inhibitor of HDACs 1, 3 and 6 [50% inhibitory concentration (IC50)=43-72 nmol/l] representing HDAC classes I and II.
M2014	MC1568	MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor with IC50 of 220 nM.
M2007	Romidepsin	Romidepsin (FK228) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.
M1993	Droxinostat	Droxinostat is a selective inhibitor of HDAC3, HDAC6 and HDAC8 with IC50 of 16.9 μM, 2.47μM and 1.46 μM, respectively.
M1876	Valproic acid sodium salt	Valproic acid (VPA) is a histone deacetylase inhibitor which is reported to enhance central GABAergic neurotransmission and inhibit Na+ channels.
M1813	PCI-24781	PCI-24781 is a novel and potent histone deacetylase (HDAC) inhibitor with IC50 value of 0.43 to 2.7 μM.
M1791	MS-275	MS-275 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM).
M1790	MGCD0103	MGCD0103 is a novel HDAC inhibitor, highly specific for classes I and IV HDACs, with IC50 of 0.15, 0.29 and 1.66 μM for HDAC 1, HDAC 2 and HDAC 3 respectively.
M1780	Vorinostat	Vorinostat (SAHA, Zolinza, MK-0683) is a selective and potent histone deacetylase (HDAC) inhibitor with the IC50 value of 10 nM for HDAC-1.
M1778	SB939	SB939 is a novel potent and orally active histone deacetylase with high tumor exposure and efficacy in mouse models of colorectal cancer.
M1775	Tubastatin A hydrochloride	Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 values of 15 nM.
M1753	Trichostatin A	Trichostatin A (TSA) is a potent, reversible inhibitor of mammalian histone deacetylase (HDAC) with IC50 value around 20 nM.
M1748	LBH589	LBH589 (Panobinostat) is a novel broad-spectrum HDAC inhibitor for MOLT-4 and Reh cells with IC50 of 5 and 20 nM, respectively.
M1747	LAQ824	LAQ824 (NVP-LAQ824) is a potent novel histone deacetylase (HDAC) inhibitor with an IC50 of 0.032 μM.
M1742	Tubacin	Tubacin (Tubulin Acetylation Inducer) is a highly potent and selective, reversible cell-permeable inhibitor of HDAC6 with IC50 of 0.004µM.
M1738	Niltubacin	Niltubacin, as an inactive derivative of Tubacin, is a highly potent and selective, reversible cell-permeable inhibitor of HDAC6.
M1730	ITF2357	ITF2357 (Givinostat, Gavinostat) is a histone deacetylase inhibitor. The IC50 values for maize HDAC preparations HD2, HD-1B and HD-1A are 10, 7.5 and 16 nM respectively.
M1722	CHR-3996	CHR-3996 is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity.
M1708	EX 527	EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 38 nM.
M1693	CUDC-101	CUDC-101 is a potent multitargeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively.
M1670	Belinostat	Belinostat (PXD101) is a novel HDAC inhibitor with an IC50 of 27 nM.

HDAC Histone deacetylases

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