Inhibitors
Cat.No. | Name | Information |
---|---|---|
M9890 | SR-4370 | SR-4370 is a potent HDAC inhibitor. |
M9638 | 4-Phenylbutyric acid (4-PBA) | 4-Phenylbutyric acid is an inhibitor of HDAC, inhibits the growth of NSCLC Cell Lines at 2 mM. |
M9633 | Tasquinimod | Tasquinimod is an oral antiangiogenic agent, it is also a S100A9 inhibitor. |
M9480 | BG45 | BG45 is a potent and selective HDAC3 inhibitor with selectivity for HDAC3 (IC50 = 289 nM) over HDAC1, 2, 6. |
M9217 | Givinostat | Givinostat is an HDAC inhibitor with IC50s of 198 and 157 nM for HDAC1 and HDAC3, respectively. |
M9206 | Biphenyl-4-sulfonyl chloride | Biphenyl-4-sulfonyl chloride is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation. |
M9153 | ACY-738 | ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM. |
M9143 | HPOB | HPOB is a highly potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 56 nM, >30 fold less potent against other HDACs. |
M9098 | HDAC8-IN-1 | HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. |
M9054 | Valproic acid | Valproic acid is an HDAC inhibitor with IC50 in the range of 0.5~2 mM. |
M7857 | ITSA-1 | ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct aceytlation events (histone and tubulin). |
M6178 | Chidamide | Chidamide is a low nanomolar inhibitor of HDAC1, 2, 3, and 10, the HDAC isotypes well documented to be associated with the malignant phenotype with IC50 values of 95, 160, 67, 78 nM for HDAC1, 2, 3, 10 respectively. |
M6176 | TMP195 | TMP195 is a selective, first-in-class, class IIa HDAC inhibitor with IC50 of 300 nM in cell-based class IIa HDAC assays. |
M6073 | WT161 | WT-161 is a potent and selective HDAC6 inhibitor with an IC50 of 0.40 nM. |
M6070 | EDO-S101 | EDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively. |
M5259 | Citarinostat | Citarinostat (ACY-241) is an orally available selective HDAC6 inhibitor with IC50 of 2.6 nM and 46 nM for HDAC6 and HDAC3, respectively. It has 13 to 18-fold selectivity towards HDAC6 in comparison to HDAC1-3. |
M5200 | BRD73954 | BRD73954 ia a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively. |
M5199 | Santacruzamate A | Santacruzamate A is a picomolar level selective inhibitor of HDAC2 with an IC50 of 85.8 nM, a Class I HDAC, with relatively little inhibition of HDAC4 or HDAC6, both Class II HDACs. |
M5152 | Sodium Butyrate | Sodium butyrate is the sodium salt of butyric acid, which has been reported to cause hyperacetylation of histones due to its role as a HDAC inhibitor with IC50 values of 0.3, 0.4, 0.3 mM for HDAC1, 2 and 7 respectively. |
M4986 | LMK-235 | LMK235 is a HDAC inhibitor, previously shown to be a novel and specific inhibitor of human HDAC4 and 5, with IC50 values of 0.49 μM (A2780) and 0.32 μM (A2780 CisR). |
M4868 | 4SC-202 | 4SC-202 is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). |
M4609 | Raddeanin-A | Raddeanin-A displays moderate inhibitory activity against histone deacetylases (HDACs) and has high antiangiogenic potency, antitumor activity. |
M3988 | Sulforaphane | Sulforaphane (SFN) extracted from broccoli sprout is an agent with potent anti-oxidant and anti-inflammatory activity. |
M3979 | Caffeic acid | Caffeic acid is an endogenous phenolic phytochemical compound that exists in plants and many foods. |
M3888 | CAY10603 | CAY10603 is a potent and selective inhibitor of HDAC6 with IC50 of 2 pM. |
M3643 | TMP269 | TMP269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively. |
M3405 | AR-42 | AR-42 is an HDAC inhibitor with IC50 of 30 nM. |
M3395 | M344 | M344 is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation. |
M3243 | Pyroxamide | Pyroxamide (NSC 696085) is a potent, affinity-purified HDAC1 inhibitor with ID50 of 100 nM. |
M3095 | Tubastatin A | Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). |
M3022 | Sodium Phenylbutyrate | Sodium Phenylbutyrate is a transcriptional regulators that act by altering chromatin structure via the modulation of HDAC activity. |
M3002 | Scriptaid | Scriptaid is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3. |
M2977 | RGFP966 | RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC. |
M2975 | RG2833 | RG2833 (RGFP109) is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively. |
M2878 | Nexturastat A | Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM, >190-fold selectivity over other HDACs. |
M2400 | Apicidin | Apicidin is a potent nonselective HDAC inhibitor with IC50 of 0.7 nM. |
M2236 | CI-994 | CI-994 (N-acetyl dinaline, PD 123654) is a novel orally active HDAC inhibitor with IC50 of 0.57 μM for HDAC1. |
M2123 | Rocilinostat | Rocilinostat (ACY-1215) is an HDAC6-selective inhibitor with IC50 of 5 nM. |
M2119 | JNJ-26481585 | JNJ-26481585 (Quisinostat) is a novel second-generation class I HDAC inhibitor. |
M2111 | CUDC-907 | CUDC-907 is a potent, orally-available small molecule dual PI3K and HDAC inhibitor. |
M2101 | PCI-34051 | PCI-34051 is a potent histone deacetylase (HDAC) 8 inhibitor with IC50 of 0.01 μM. |
M2095 | Resminostat | Resminostat is a potent inhibitor of HDACs 1, 3 and 6 [50% inhibitory concentration (IC50)=43-72 nmol/l] representing HDAC classes I and II. |
M2014 | MC1568 | MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor with IC50 of 220 nM. |
M2007 | Romidepsin (FK228) | Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively. |
M1993 | Droxinostat | Droxinostat is a selective inhibitor of HDAC3, HDAC6 and HDAC8 with IC50 of 16.9 μM, 2.47μM and 1.46 μM, respectively. |
M1876 | Valproic acid sodium salt | Valproic acid (VPA) is a histone deacetylase inhibitor which is reported to enhance central GABAergic neurotransmission and inhibit Na+ channels. |
M1813 | PCI-24781 | PCI-24781 is a novel and potent histone deacetylase (HDAC) inhibitor with IC50 value of 0.43 to 2.7 μM. |
M1791 | MS-275 | MS-275 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM). |
M1790 | MGCD0103 | MGCD0103 is a novel HDAC inhibitor, highly specific for classes I and IV HDACs, with IC50 of 0.15, 0.29 and 1.66 μM for HDAC 1, HDAC 2 and HDAC 3 respectively. |
M1780 | Vorinostat | Vorinostat (SAHA, Zolinza, MK-0683) is a selective and potent histone deacetylase (HDAC) inhibitor with the IC50 value of 10 nM for HDAC-1. |
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