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MC1568

Cat. No. M2014
MC1568 Structure
Size Price Availability Quantity
10mg USD 50 In stock
50mg USD 150 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

MC1568 is a selective inhibitor of class IIa histone deacetylases (HDACs). In vivo, MC1568 shows an apparent tissue-selective HDAC inhibition. In skeletal muscle and heart, MC1568 inhibits the activity of HDAC4 and HDAC5 without affecting HDAC3 activity, thereby leaving MEF2-HDAC complexes in a repressed state. In F9 cells, MC1568 specifically blocks endodermal differentiation despite not affecting retinoic acid-induced maturation of promyelocytic NB4 cells. In 3T3-L1 cells, MC1568 attenuates PPARγ-induced adipogenesis. Finally, treatment of pancreatic explants with the selective class IIa HDAC inhibitor MC1568 enhances expression of Pax4, a key factor required for proper β-and δ-cell differentiation and amplifies endocrine β- and δ-cells.

Customer Product Validations & Biological Datas
Source Toxicol Sci (2016). Figure 1. MC1568
Method Cell Viability
Cell Lines SH-SY5Y cells
Concentrations 5 μM
Incubation Time 24h
Results Interestingly, cell viability was significantly ameliorated when cells were pretreated with MC1568, but not with MS275 compared with cells exposed to thimerosal alone
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 314.31
Formula C17H15FN2O3
CAS Number 852475-26-4
Purity >98%
Solubility DMSO
Storage at -20°C
References

Specific control of pancreatic endocrine β- and δ-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9.
Lenoir O, et al. Diabetes. 2011 Nov;60(11):2861-71. PMID: 21953612.

HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation.
Nebbioso A, et al. J Mol Endocrinol. 2010 Oct;45(4):219-28. PMID: 20639404.

Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes.
Nebbioso A, et al. EMBO Rep. 2009 Jul;10(7):776-82. PMID: 19498465.

Specific activity of class II histone deacetylases in human breast cancer cells.
Duong V, et al. Mol Cancer Res. 2008 Dec;6(12):1908-19. PMID: 19074835.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: MC1568 supplier, HDAC, inhibitors

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