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Romidepsin

Cat. No. M2007
Romidepsin Structure
Synonym:

FK228, ISTODAX

Size Price Availability Quantity
1mg USD 120 In stock
5mg USD 350 In stock
10mg USD 535 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Romidepsin (FK228) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively. Romidepsin inhibits the growth of U-937, K562, and CCRF-CEM cells with IC50 of 5.92 nM, 8.36 nM, and 6.95 nM, respectively. Romidepsin exhibits concentration-dependent cytotoxicity against a panel of mantle cell lymphoma (MCL) cell lines. FK228 (Romidepsin) treatment potently inhibits the neovascularization of chick embryo and that of adult mice in the Matrigel plug assay. FK228(Romidepsin) is currently in a Phase I study in treating patients with lymphoma, chronic lymphocytic leukemia, or solid tumors with liver dysfunction.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 540.7
Formula C24H36N4O6S2
CAS Number 128517-07-7
Purity >99%
Solubility DMSO
Storage at -20°C
References

Results from a pivotal, open-label, phase II study of romidepsin in relapsed or refractory peripheral T-cell lymphoma after prior systemic therapy.
Coiffier B, et al. J Clin Oncol. 2012 Feb 20;30(6):631-6. PMID: 22271479.

Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma.
Piekarz RL, et al. Blood. 2011 Jun 2;117(22):5827-34. PMID: 21355097.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Romidepsin, FK228, ISTODAX supplier, HDAC, inhibitors

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