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Tubastatin A

Cat. No. M3095
Tubastatin A Structure
Size Price Availability Quantity
50mg USD 90 In stock
100mg USD 160 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).

Protocol
Cell Experiment
Cell lines normal human (i.e., H69) and rat (NRC) cholangiocyte cell lines
Preparation method Proliferation assays
Proliferation assays were conducted using the CellTiter 96 AQueous Non-Radioactive Cell Proliferation Assay (MTS; Promega) and/or counting cells using the Cellometer Auto4 (Nexcelom Bioscience) cell counter.
Concentrations 0, 4 µ M
Incubation time 3 days
Animal Experiment
Animal models orthotopic, syngeneic CCA model in rats
Formulation saline
Dosages 10 mg/kg daily for 7 days
Administration intraperitoneally
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 335.4
Formula C20H21N3O2
CAS Number 1252003-15-8
Purity >98%
Solubility DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tubastatin A supplier, HDAC, inhibitors

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