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4-Phenylbutyric acid (4-PBA)

Cat. No. M9638
4-Phenylbutyric acid (4-PBA) Structure
Synonym:

4-PBA; Benzenebutyric acid

Size Price Availability Quantity
100mg USD 38 In stock
500mg USD 44 In stock
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Quality Control
Biological Activity

4-Phenylbutyric acid is an inhibitor of HDAC, inhibits the growth of NSCLC Cell Lines at 2 mM. 4-Phenylbutyric acid is also an inhibitor of endoplasmic reticulum (ER) stress. 4-Phenylbutyric acid (0-5 mM) inhibits ASFV infection in a dose-dependent manner. LPS decreases the level of p62, whereas 4-Phenylbutyric acid reverses this decrease upon LPS stimulation for 48 h. The percentage of cells with LPS-induced AVOs is increased at 48 h, whereas 4-Phenylbutyric acid significantly reduces this percentage. Specifically, the percentage of cells with AVOs decreases from 61.6% to 53.1% upon 4-Phenylbutyric acid treatment, supporting that 4-Phenylbutyric acid inhibits LPS-induced autophagy.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 164.2
Formula C10H12O2
CAS Number 1821-12-1
Purity >99%
Solubility DMSO ≥ 30 mg/mL
Water 3 mg/mL at 40 ºC
Storage 2-8°C, dry, protect from light, sealed
References

4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts
Hyun-Jung Park, et al. Biochem Pharmacol. 2018 May;151:9-17. PMID: 29458048.

Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14
Goncalo Frouco, et al. Virus Res. 2017 Oct 15;242:24-29. PMID: 28916365.

Perfluorooctanoic acid exposure induces endoplasmic reticulum stress in the liver and its effects are ameliorated by 4-phenylbutyrate
Shengmin Yan, et al. Free Radic Biol Med. 2015 Oct;87:300-11. PMID: 26159507.

Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung
Tsg-Hui Chang, et al. Clin Cancer Res. 2002 Apr;8(4):1206-12. PMID: 11948134.

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Keywords: 4-Phenylbutyric acid (4-PBA), 4-PBA; Benzenebutyric acid supplier, HDAC, inhibitors

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