4-Phenylbutyric acid is an inhibitor of HDAC, inhibits the growth of NSCLC Cell Lines at 2 mM. 4-Phenylbutyric acid is also an inhibitor of endoplasmic reticulum (ER) stress. 4-Phenylbutyric acid (0-5 mM) inhibits ASFV infection in a dose-dependent manner. LPS decreases the level of p62, whereas 4-Phenylbutyric acid reverses this decrease upon LPS stimulation for 48 h. The percentage of cells with LPS-induced AVOs is increased at 48 h, whereas 4-Phenylbutyric acid significantly reduces this percentage. Specifically, the percentage of cells with AVOs decreases from 61.6% to 53.1% upon 4-Phenylbutyric acid treatment, supporting that 4-Phenylbutyric acid inhibits LPS-induced autophagy.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO ≥ 30 mg/mL
Water 3 mg/mL at 40 ºC
|Storage||2-8°C, dry, protect from light, sealed|
4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts
Hyun-Jung Park, et al. Biochem Pharmacol. 2018 May;151:9-17. PMID: 29458048.
Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14
Goncalo Frouco, et al. Virus Res. 2017 Oct 15;242:24-29. PMID: 28916365.
Perfluorooctanoic acid exposure induces endoplasmic reticulum stress in the liver and its effects are ameliorated by 4-phenylbutyrate
Shengmin Yan, et al. Free Radic Biol Med. 2015 Oct;87:300-11. PMID: 26159507.
Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung
Tsg-Hui Chang, et al. Clin Cancer Res. 2002 Apr;8(4):1206-12. PMID: 11948134.
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ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM.
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