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RGFP966

Cat. No. M2977
RGFP966 Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 110 In stock
50mg USD 340 In stock
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Quality Control
Biological Activity

RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC.

Customer Product Validations & Biological Datas
Source EMBO Mol Med (2018). Figure 2. RGFP966
Method Western blots
Cell Lines C4-2 cells
Concentrations 3 μM
Incubation Time 24 h
Results The HDAC3 inhibitor RGFP966 also undermined AKT ubiquitination
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 362.4
Formula C21H19FN4O
CAS Number 1396841-57-8
Purity >99%
Solubility DMSO 60 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: RGFP966 supplier, HDAC, inhibitors

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