Free shipping on all orders over $ 500

RGFP966

Cat. No. M2977
RGFP966 Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 110 In stock
50mg USD 340 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC.

Customer Product Validations & Biological Datas
Source EMBO Mol Med (2018). Figure 2. RGFP966
Method Western blots
Cell Lines C4-2 cells
Concentrations 3 μM
Incubation Time 24 h
Results The HDAC3 inhibitor RGFP966 also undermined AKT ubiquitination
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 362.4
Formula C21H19FN4O
CAS Number 1396841-57-8
Purity >99%
Solubility DMSO 60 mg/mL
Storage at -20°C
Related HDAC Products
Givinostat

Givinostat is an HDAC inhibitor with IC50s of 198 and 157 nM for HDAC1 and HDAC3, respectively.

Biphenyl-4-sulfonyl chloride

Biphenyl-4-sulfonyl chloride is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation.

ACY-738

ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM.

HPOB

HPOB is a highly potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 56 nM, >30 fold less potent against other HDACs.

HDAC8-IN-1

HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: RGFP966 supplier, HDAC, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.