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Cat. No. M4986
LMK-235 Structure
Size Price Availability Quantity
10mM*1mL In DMSO USD 56 In stock
5mg USD 50 In stock
10mg USD 80 In stock
50mg USD 250 In stock
100mg USD 450 In stock
200mg USD 800 In stock
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Quality Control
Biological Activity

In the cisplatin-resistant HNSCC cell lines Cal27 CisR and Kyse510, LMK-235 enhanced markedly the cytotoxicity of cisplatin.A comparison of the IC50 values of the four most potent compounds with those obtained for HepG2 cells (Table 2) indicates that LMK-235 is cytotoxic.

Customer Product Validations & Biological Datas
Source Cell Death Differ (2017). Figure 1. LMK-235
Method Cell viability
Cell Lines Human third molars
Concentrations 50 and 100 nM
Incubation Time 3 days
Results In addition, the proliferation of the 1,000 nM group was reduced at days 1, 5 and 7 compared with the 0 nM group. However, low concentrations of LMK-235 (50 and 100 nM) barely affected the proliferation of DPCs
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 294.35
Formula C15H22N2O4
CAS Number 1418033-25-6
Purity >99%
Solubility DMSO 30mg/mL
Storage at -20°C
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Abmole Inhibitor Catalog 2017

Keywords: LMK-235 supplier, HDAC, inhibitors

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