In the cisplatin-resistant HNSCC cell lines Cal27 CisR and Kyse510, LMK-235 enhanced markedly the cytotoxicity of cisplatin.A comparison of the IC50 values of the four most potent compounds with those obtained for HepG2 cells (Table 2) indicates that LMK-235 is cytotoxic.
Life Sci. 2023 Dec 1;1:334:122173.
Applying HDACis to increase SSTR2 expression and radiolabeled DOTA-TATE uptake: From cells to mice
LMK-235 purchased from AbMole
Cancers (Basel). 2021 Sep 29;13(19):4905.
Comparing the Effect of Multiple Histone Deacetylase Inhibitors on SSTR2 Expression and [111In]In-DOTATATE Uptake in NET Cells
LMK-235 purchased from AbMole
 |
Source | Cell Death Differ (2017). Figure 1. LMK-235 |
| Method | Cell viability | |
| Cell Lines | Human third molars | |
| Concentrations | 50 and 100 nM | |
| Incubation Time | 3 days | |
| Results | In addition, the proliferation of the 1,000 nM group was reduced at days 1, 5 and 7 compared with the 0 nM group. However, low concentrations of LMK-235 (50 and 100 nM) barely affected the proliferation of DPCs |
| Molecular Weight | 294.35 |
| Formula | C15H22N2O4 |
| CAS Number | 1418033-25-6 |
| Solubility (25°C) | DMSO 27 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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