In the cisplatin-resistant HNSCC cell lines Cal27 CisR and Kyse510, LMK-235 enhanced markedly the cytotoxicity of cisplatin.A comparison of the IC50 values of the four most potent compounds with those obtained for HepG2 cells (Table 2) indicates that LMK-235 is cytotoxic.
|Source||Cell Death Differ (2017). Figure 1. LMK-235|
|Cell Lines||Human third molars|
|Concentrations||50 and 100 nM|
|Incubation Time||3 days|
|Results||In addition, the proliferation of the 1,000 nM group was reduced at days 1, 5 and 7 compared with the 0 nM group. However, low concentrations of LMK-235 (50 and 100 nM) barely affected the proliferation of DPCs|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
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