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Dihydrotestosterone

Cat. No. M6033

Dihydrotestosterone Structure
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Biological Activity

Dihydrotestosterone is a hormone with powerful androgenic actions, causes the body to mature during puberty and is responsible for many of the physical characteristics associated with adult males.

Protocol
Cell Experiment
Cell lines Primary pig hepatocytes
Preparation method In steroid metabolism studies, hepatocytes were incubated in 10 ml of basal growth medium containing phenol red-free DMEM with 10% of charcoal treated FBS fortified with 10 µM (final concentration) of androstenone, 17β-estradiol or dihydrotestosterone.
Concentrations 10 µM
Incubation time 48 h
Animal Experiment
Animal models
Formulation
Dosages
Administration
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 290.44
Formula C19H30O2
CAS Number 521-18-6
Purity >99%
Solubility 72.5 mg/mL in DMSO
Storage at -20°C
References

Metabolism of androstenone, 17β-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3β-hydroxysteroid dehydrogenase in this process.
Chen G, et al. PLoS One. 2015 Jan 15;10(1):e113194. PMID: 25590624.

Design and synthesis of new dihydrotestosterone derivative with positive inotropic activity.
Lauro FV, et al. Steroids. 2015 Mar;95:39-50. PMID: 25578737.

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