Dihydrotestosterone is a hormone with powerful androgenic actions, causes the body to mature during puberty and is responsible for many of the physical characteristics associated with adult males. It can be used to construct animal models of polycystic ovary syndrome (PCOS).
BMC Women's Health. 2024 Jan;25.
PHLPP1 inhibits the growth and aerobic glycolysis activity of human ovarian granular cells through inactivating AKT pathway
Dihydrotestosterone purchased from AbMole
Drug Chem Toxicol. 2016 Oct;39(4):392-9.
Effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage
Dihydrotestosterone purchased from AbMole
J Steroid Biochem Mol Biol. 2013 Nov;138:54-62.
Effect of androgens on different breast cancer cells co-cultured with or without breast adipose fibroblasts
Dihydrotestosterone purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | Primary pig hepatocytes |
| Preparation method | In steroid metabolism studies, hepatocytes were incubated in 10 ml of basal growth medium containing phenol red-free DMEM with 10% of charcoal treated FBS fortified with 10 µM (final concentration) of androstenone, 17β-estradiol or dihydrotestosterone. |
| Concentrations | 10 µM |
| Incubation time | 48 h |
| Animal Experiment | |
|---|---|
| Animal models | SOD1-G93A mutant mice with the congenic C57BL/6J background |
| Formulation | Saline |
| Dosages | 5 mg |
| Administration | silastic implant |
| Molecular Weight | 290.44 |
| Formula | C19H30O2 |
| CAS Number | 521-18-6 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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