Fluorescein Sodium is a phthalic indicator dye used as a diagnostic aid in corneal injuries and corneal trauma.
Exp Eye Res. 2023 Apr 18;231:109474.
Inhibition of AIF-1 alleviates laser-induced macular neovascularization by inhibiting endothelial cell proliferation via restrained p44/42 MAPK signaling pathway
Fluorescein Sodium purchased from AbMole
Front Bioeng Biotechnol. 2022 Jun 1;10:913648.
Mussel-Inspired Microgel Encapsulated NLRP3 Inhibitor as a Synergistic Strategy Against Dry Ey
Fluorescein Sodium purchased from AbMole
SSRN. 2022 Apr.
Inhibition of TREM-1 Alleviates Choroidal Neovascularization in a Mouse Model
Fluorescein Sodium purchased from AbMole
| Molecular Weight | 376.27 |
| Formula | C20H10Na2O5 |
| CAS Number | 518-47-8 |
| Solubility (25°C) | Water ≥ 100 mg/mL |
| Storage | RT, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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