Synonym: NSC 177382, TN
Tunicamycin inhibits GlcNAc phosphotransferase (GPT).Tunicamycin blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis.Tunicamycin can be used to induce autophagy.Tunicamycin induces apoptosis in association with caspase-3 activation, generation of reactive oxygen species (ROS), and downregulation of survivin expression.P38 MAPK (mitogen-activated protein kinase) and the generation of ROS signaling pathway play crucial roles in TN-induced apoptosis in U937 cells.TN modulates multiple components of the apoptotic response of human leukemia cells and raise the possibility of a novel therapeutic strategy for hematological malignancies.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Tunicamycin promotes apoptosis in leukemia cells through ROS generation and downregulation of survivin expression.
Lim EJ, et al. Apoptosis. 2015 May 29. PMID: 26022098.
Primary murine airway smooth muscle cells exposed to poly(I,C) or tunicamycin synthesize a leukocyte-adhesive hyaluronan matrix.
Lauer ME, et al. J Biol Chem. 2009 Feb 20;284(8):5299-312. PMID: 19088077.
The hepatitis B virus precore protein is retrotransported from endoplasmic reticulum (ER) to cytosol through the ER-associated degradation pathway.
Duriez M, et al. J Biol Chem. 2008 Nov 21;283(47):32352-60. PMID: 18805786.
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