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Tunicamycin

Cat. No. M4798
Tunicamycin Structure
Synonym:

NSC 177382, TN

Size Price Availability Quantity
5mg USD 280 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Tunicamycin inhibits GlcNAc phosphotransferase (GPT).Tunicamycin blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis.Tunicamycin can be used to induce autophagy.Tunicamycin induces apoptosis in association with caspase-3 activation, generation of reactive oxygen species (ROS), and downregulation of survivin expression.P38 MAPK (mitogen-activated protein kinase) and the generation of ROS signaling pathway play crucial roles in TN-induced apoptosis in U937 cells.TN modulates multiple components of the apoptotic response of human leukemia cells and raise the possibility of a novel therapeutic strategy for hematological malignancies.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 816.89
Formula C37H60N4O16
CAS Number 11089-65-9
Purity >99%
Solubility DMSO
Storage at -20°C
References

Tunicamycin promotes apoptosis in leukemia cells through ROS generation and downregulation of survivin expression.
Lim EJ, et al. Apoptosis. 2015 May 29. PMID: 26022098.

Primary murine airway smooth muscle cells exposed to poly(I,C) or tunicamycin synthesize a leukocyte-adhesive hyaluronan matrix.
Lauer ME, et al. J Biol Chem. 2009 Feb 20;284(8):5299-312. PMID: 19088077.

The hepatitis B virus precore protein is retrotransported from endoplasmic reticulum (ER) to cytosol through the ER-associated degradation pathway.
Duriez M, et al. J Biol Chem. 2008 Nov 21;283(47):32352-60. PMID: 18805786.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tunicamycin, NSC 177382, TN supplier, Transferase, inhibitors

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