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Tunicamycin

Cat. No. M4798
Tunicamycin Structure
Synonym:

NSC 177382, TN

Size Price Availability Quantity
1mg USD 112  USD140 In stock
5mg USD 288  USD360 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tunicamycin inhibits GlcNAc phosphotransferase (GPT).Tunicamycin blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis.Tunicamycin can be used to induce autophagy.Tunicamycin induces apoptosis in association with caspase-3 activation, generation of reactive oxygen species (ROS), and downregulation of survivin expression.P38 MAPK (mitogen-activated protein kinase) and the generation of ROS signaling pathway play crucial roles in TN-induced apoptosis in U937 cells.TN modulates multiple components of the apoptotic response of human leukemia cells and raise the possibility of a novel therapeutic strategy for hematological malignancies.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 816.89
Formula C37H60N4O16
CAS Number 11089-65-9
Purity >98%
Solubility DMSO 10 mM
Storage 2-8°C, dry, protect from light, sealed
References

[1] Lim EJ, et al. Apoptosis. Tunicamycin promotes apoptosis in leukemia cells through ROS generation and downregulation of survivin expression.

[2] Lauer ME, et al. J Biol Chem. Primary murine airway smooth muscle cells exposed to poly(I,C) or tunicamycin synthesize a leukocyte-adhesive hyaluronan matrix.

[3] Duriez M, et al. J Biol Chem. The hepatitis B virus precore protein is retrotransported from endoplasmic reticulum (ER) to cytosol through the ER-associated degradation pathway.

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Keywords: Tunicamycin, NSC 177382, TN supplier, Transferase, inhibitors

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