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ZCL278

Cat. No. M2562
ZCL278 Structure
Size Price Availability Quantity
10mg USD 78 In stock
50mg USD 230 In stock
100mg USD 348 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 584.89
Formula C21H19BrClN5O4S2
CAS Number 587841-73-4
Purity >99%
Solubility DMSO 90 mg/mL
Storage at -20°C
Customer Product Validations & Biological Datas
Source ACS Appl Mater Interfaces (2017). Figure 9. ZCL 278 (Abmole BioScience. Houston, TX, USA)
Method Transwells
Cell Lines MDCK cells
Concentrations
Incubation Time
Results As shown in Figure 9, in the presence of ZCL 278, the transmembrane amount of PTX-NCs was reduced significantly, indicating that Cdc 42 participated in the regulation of the transport of PTX-NCs.
Rating
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: ZCL278 supplier, inhibitors

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