|M9235||ARS-853||ARS-853 is a selective, covalent KRASG12C inhibitor with an IC50 of 2.5 μM.|
|M9047||ARS-1630||ARS-1630 is a novel mutant K-ras G12C inhibitor.|
|M9046||ARS-1323||ARS-1323 is a novel inhibitor of mutant K-ras G12C.|
|M9045||ARS-1620||ARS-1620 is an atropisomeric selective KRAS-G12C inhibitor with desirable pharmacokinetics.|
|M9000||ML-098||ML-098 is an activator of the GTP-binding protein Rab7 with EC50 value of 77.6 nM.|
|M8999||CCG-1423||CCG-1423 is a novel specific inhibitor of RhoA transcriptional signaling.|
|M8954||Kobe2602||Kobe2602 is analog of Kobe0065, inhibits binding of H-Ras·GTP to c-Raf-1 with a Ki value of 149 ± 55 μM.|
|M6704||EHT 1864||EHT 1864 is a potent inhibitor of Rac family GTPases.|
|M6282||NSC 23766||NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA.|
|M5946||Salirasib||Salirasib is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Phase 2.|
|M3663||K-Ras(G12C) inhibitor 9||K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).|
|M2608||Kobe0065||Kobe0065 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD, exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM.|
|M2562||ZCL278||ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.|
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