Catalog

Ras Ras

Inhibitors

Cat.No.	Name	Information
M9817	MLS000532223	MLS000532223 is a selective inhibitor of Rho family GTPases, with EC50 ranging from 16 μM to 120 μM.
M9801	BI-3406	BI-3406 is a highly potent and selective SOS1::KRAS inhibitor (IC50=6 nM), which selectively binds to SOS1 and blocks the interaction with KRAS, irrespective of the KRAS mutation.
M9586	ZT-12-037-01	ZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor with IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively.
M9578	BI-2852	BI-2852 is a potent KRAS inhibitor that binds with nanomolar affinity to a pocket.
M9428	MRTX849	MRTX849 is a potent, highly selective, oral available KRAS G12C inhibitor.
M9359	BAY-293	BAY-293 is a potent inhibitor of Son of Sevenless 1 (SOS1), blocks RAS activation via disruption of the KRAS-SOS1 interaction with an IC50 of 21 nM.
M9357	AMG-510 racemate	AMG-510 racemate is a racemic of AMG-510, which is a potent KRAS G12C covalent inhibitor.
M9356	AMG-510 (Sotorasib)	AMG-510 (Sotorasib) is a potent KRAS G12C covalent inhibitor.
M9235	ARS-853	ARS-853 is a selective, covalent KRAS^G12C inhibitor with an IC50 of 2.5 μM.
M9047	ARS-1630	ARS-1630 is a novel mutant K-ras G12C inhibitor.
M9046	ARS-1323	ARS-1323 is a novel inhibitor of mutant K-ras G12C.
M9045	ARS-1620	ARS-1620 is an atropisomeric selective KRAS-G12C inhibitor with desirable pharmacokinetics.
M9000	ML-098	ML-098 is an activator of the GTP-binding protein Rab7 with EC50 value of 77.6 nM.
M8999	CCG-1423	CCG-1423 is a novel specific inhibitor of RhoA transcriptional signaling.
M8954	Kobe2602	Kobe2602 is analog of Kobe0065, inhibits binding of H-Ras·GTP to c-Raf-1 with a Ki value of 149 ± 55 μM.
M8533	CCG-203971	CCG-203971 is an inhibitor of the Rho/MKL1/SRF transcriptional pathway, which has been shown to play a role in metastasis of melanoma and breast cancer and clinically associated with castration-resistant prostate cancer.
M6704	EHT 1864 2HCl	EHT 1864 is a potent inhibitor of Rac family GTPases.
M6282	NSC 23766	NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA.
M5946	Salirasib	Salirasib is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Phase 2.
M5481	CASIN	CASIN is a selective GTPase Cdc42 inhibitor with IC50 of 2 uM.
M3663	K-Ras(G12C) inhibitor 9	K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).
M2608	Kobe0065	Kobe0065 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD, exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM.
M2562	ZCL278	ZCL278 is a selective Cdc42 GTPase inhibitor with K_d of 11.4 μM.

Signaling Pathways

Product Type

Ras Ras

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