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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M9428 | MRTX849 | MRTX849 is a potent, highly selective, oral available KRAS G12C inhibitor. |
| M9359 | BAY-293 | BAY-293 is a potent inhibitor of Son of Sevenless 1 (SOS1), blocks RAS activation via disruption of the KRAS-SOS1 interaction with an IC50 of 21 nM. |
| M9357 | AMG-510 racemate | AMG-510 racemate is a racemic of AMG-510, which is a potent KRAS G12C covalent inhibitor. |
| M9356 | AMG-510 | AMG-510 is a potent KRAS G12C covalent inhibitor. |
| M9235 | ARS-853 | ARS-853 is a selective, covalent KRASG12C inhibitor with an IC50 of 2.5 μM. |
| M9047 | ARS-1630 | ARS-1630 is a novel mutant K-ras G12C inhibitor. |
| M9046 | ARS-1323 | ARS-1323 is a novel inhibitor of mutant K-ras G12C. |
| M9045 | ARS-1620 | ARS-1620 is an atropisomeric selective KRAS-G12C inhibitor with desirable pharmacokinetics. |
| M9000 | ML-098 | ML-098 is an activator of the GTP-binding protein Rab7 with EC50 value of 77.6 nM. |
| M8999 | CCG-1423 | CCG-1423 is a novel specific inhibitor of RhoA transcriptional signaling. |
| M8954 | Kobe2602 | Kobe2602 is analog of Kobe0065, inhibits binding of H-Ras·GTP to c-Raf-1 with a Ki value of 149 ± 55 μM. |
| M8533 | CCG-203971 | CCG-203971 is an inhibitor of the Rho/MKL1/SRF transcriptional pathway, which has been shown to play a role in metastasis of melanoma and breast cancer and clinically associated with castration-resistant prostate cancer. |
| M6704 | EHT 1864 | EHT 1864 is a potent inhibitor of Rac family GTPases. |
| M6282 | NSC 23766 | NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA. |
| M5946 | Salirasib | Salirasib is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Phase 2. |
| M3663 | K-Ras(G12C) inhibitor 9 | K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C). |
| M2608 | Kobe0065 | Kobe0065 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD, exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM. |
| M2562 | ZCL278 | ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM. |
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