Catalog

Ras Ras

Inhibitors

Cat.No.	Name	Information
M9047	ARS-1630	ARS-1630 is a novel mutant K-ras G12C inhibitor.
M9046	ARS-1323	ARS-1323 is a novel inhibitor of mutant K-ras G12C.
M9045	ARS-1620	ARS-1620 is an atropisomeric selective KRAS-G12C inhibitor with desirable pharmacokinetics.
M9000	ML-098	ML-098 is an activator of the GTP-binding protein Rab7 with EC50 value of 77.6 nM.
M8999	CCG-1423	CCG-1423 is a novel specific inhibitor of RhoA transcriptional signaling.
M8954	Kobe2602	Kobe2602 is analog of Kobe0065, inhibits binding of H-Ras·GTP to c-Raf-1 with a Ki value of 149 ± 55 μM.
M6704	EHT 1864	EHT 1864 is a potent inhibitor of Rac family GTPases.
M6282	NSC 23766	NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA.
M5946	Salirasib	Salirasib is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Phase 2.
M2608	Kobe0065	Kobe0065 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD, exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM.
M2562	ZCL278	ZCL278 is a selective Cdc42 GTPase inhibitor with K_d of 11.4 μM.