| Cat.No. | Name | Information |
|---|---|---|
| M2562 | ZCL278 | ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM. |
| M6282 | NSC 23766 | NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA. |
| M9356 | AMG-510 (Sotorasib) | AMG-510 (Sotorasib) is a potent KRAS G12C covalent inhibitor. |
| M9428 | MRTX849 (Adagrasib) | MRTX849 (Adagrasib) is a potent, highly selective, oral available KRAS G12C inhibitor. |
| M10600 | SAH-SOS1A TFA | SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM) and directly and independently blocks nucleotide association. |
| M10593 | MRTX1133 | MRTX1133 is a first-in-class, potent and highly selective KRAS G12D inhibitor. MRTX1133 targets the KRAS G12D protein in both active and inactive states. MRTX1133 selectively inhibits KRAS G12D mutant, but not KRAS wild-type, tumor cells. |
| M10498 | CCG-222740 | CCG-222740 is a selective, orally active Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. |
| M10268 | CID-1067700 (ML282) | CID-1067700 (ML282) is a competitive inhibitors of nucleotide binding by Ras-related GTPases with a Ki of 13 nM for Rab7. |
| M9817 | MLS000532223 | MLS000532223 is a selective inhibitor of Rho family GTPases, with EC50 ranging from 16 μM to 120 μM. |
| M9801 | BI-3406 | BI-3406 is a highly potent and selective SOS1::KRAS inhibitor (IC50=6 nM), which selectively binds to SOS1 and blocks the interaction with KRAS, irrespective of the KRAS mutation. |
| M9586 | ZT-12-037-01 | ZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor with IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. |
| M9578 | BI-2852 | BI-2852 is a potent KRAS inhibitor that binds with nanomolar affinity to a pocket. |
| M9359 | BAY-293 | BAY-293 is a potent inhibitor of Son of Sevenless 1 (SOS1), blocks RAS activation via disruption of the KRAS-SOS1 interaction with an IC50 of 21 nM. |
| M9357 | AMG-510 racemate | AMG-510 racemate is a racemic of AMG-510, which is a potent KRAS G12C covalent inhibitor. |
| M9235 | ARS-853 | ARS-853 is a selective, covalent KRASG12C inhibitor with an IC50 of 2.5 μM. |
| M9047 | ARS-1630 | ARS-1630 is a novel mutant K-ras G12C inhibitor. |
| M9046 | ARS-1323 | ARS-1323 is a novel inhibitor of mutant K-ras G12C. |
| M9045 | ARS-1620 | ARS-1620 is an atropisomeric selective KRAS-G12C inhibitor with desirable pharmacokinetics. |
| M9000 | ML-098 | ML-098 is an activator of the GTP-binding protein Rab7 with EC50 value of 77.6 nM. |
| M8999 | CCG-1423 | CCG-1423 is a novel specific inhibitor of RhoA transcriptional signaling. |
| M8954 | Kobe2602 | Kobe2602 is analog of Kobe0065, inhibits binding of H-Ras·GTP to c-Raf-1 with a Ki value of 149 ± 55 μM. |
| M8533 | CCG-203971 | CCG-203971 is an inhibitor of the Rho/MKL1/SRF transcriptional pathway, which has been shown to play a role in metastasis of melanoma and breast cancer and clinically associated with castration-resistant prostate cancer. |
| M7194 | Rhosin hydrochloride | Rhosin hydrochloride is a rho GTPase inhibitor. |
| M6968 | ML141 (CID-2950007) | ML141 (CID-2950007) is a selective inhibitor of Cdc42 Rho family GTPase. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
