All AbMole products are for research use only, cannot be used for human consumption.
Capsaicin is an active component of chili peppers, which are plants belonging to the genus Capsicum. The burning and painful sensations associated with capsaicin result from its chemical interaction with sensory neurons. Capsaicin, as a member of the vanilloid family, binds to a receptor called the vanilloid receptor subtype 1 (VR1). By binding to the VR1 receptor, the capsaicin molecule produces the same sensation that excessive heat or abrasive damage would cause, explaining why the spiciness of capsaicin is described as a burning sensation.
Phytomedicine. 2024 Oct 07.
Z-Ligustilide Alleviates Atherosclerosis by Reconstructing Gut Microbiota and Sustaining Gut Barrier Integrity through Activation of Cannabinoid Receptor 2
Capsaicin purchased from AbMole
ACS Biomater Sci Eng. 2024 May 13;10(5):2995-3005.
Ca2+ Overload Decreased Cellular Viability in Magnetic Hyperthermia without a Macroscopic Temperature Rise
Capsaicin purchased from AbMole
J Periodontal Res. 2024 Dec 01.
TRPV1 Promotes Periodontitis Tissue Inflammation and Oxidative Damage by Regulating STAT3 Signaling Pathway
Capsaicin purchased from AbMole
Signal Transduct Target Ther. 2023 Aug 7;8(1):292.
Extracellular RNAs-TLR3 signaling contributes to cognitive impairment after chronic neuropathic pain in mice
Capsaicin purchased from AbMole
Cell Signal. 2023 Jun 17.
Neuronal TRPV1-CGRP axis regulates bone defect repair through Hippo signaling pathway
Capsaicin purchased from AbMole
Iran J Basic Med Sci. 2022 May;25(5):635-642.
Transient receptor potential vanilloid type-1 regulates periodontal disease damage via the PI3K/AKT signaling pathway
Capsaicin purchased from AbMole
| Molecular Weight | 305.41 |
| Formula | C18H27NO3 |
| CAS Number | 404-86-4 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage | 2-8°C, protect from light |
[1] Wytske Fokkens, et al. Capsaicin for Rhinitis
[2] Angela M Chapa-Oliver, et al. Capsaicin: From Plants to a Cancer-Suppressing Agent
[3] Ruth Clark, et al. Anticancer Properties of Capsaicin Against Human Cancer
[5] Surinder Kumar Sharma, et al. Mechanisms and clinical uses of capsaicin
| Related TRP Channel Products |
|---|
| Moringin
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC50 of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. |
| (S)-ABT-102
(S)-ABT-102 is a potent TRPV1 antagonist, with an IC50 of 123 nM. (S)-ABT-102 can block the activation of TRPV1 by capsaicin. |
| Oleoyl Serotonin
Oleoyl Serotonin is a TRPV1 antagonist with IC50 value of 2.57 μM for human TRPV1. |
| ABT-102
ABT-102 (CHEMBL398338) is a potent and highly selective transient receptor potential vanilloid 1 (TRPV1) receptor antagonist. |
| MK-2295
MK-2295 (TRPV1 antagonist 5) is a potent TRPV1 antagonist. MK-2295 can be used for the research of chronic pain. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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