Free shipping on all orders over $ 500

Testosterone

Cat. No. M6105
Testosterone Structure
Synonym:

(+)-Testosterone

Size Price Availability Quantity
100mg USD 80 In stock
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Testosterone modulates vascular endothelial cell (EC) growth and platelet aggregation through its direct action on endothelial NO production. Testosterone stimulates NO synthesis via its direct action on ECs. Testosterone involves a nongenomic stimulation of NO synthesis, which depends on calcium influx from the extracellular medium and on MAPK and PKC pathways. Testosterone increases EC growth in bovine aortic and in vein ECs. Testosterone stimulates EC migration. Testosterone stimulates VEGF and NOS expression and promotes capillary formation in the cerebral vascular system. In fact, in bovine aortic ECs, Testosterone and DHEA promote EC proliferation, migration, and vascular tube formation, effects dependent on PTX-sensitive G protein and ERK1/2 activation[1] The calculated EC50 value of morning Testosterone corresponding to a 50% increase in the pubertal growth ratio is 3.1 nM (2.4-4.2, r2=0.84) using the dose-response model. Growth velocity increases by 50% from prepubertal growth to PHV at a morning Testosterone level of 3.1 nM (95% confidence interval 2.4-4.2), EC50.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 288.42
Formula C19H28O2
CAS Number 58-22-0
Purity >99%
Solubility 52 mg/mL in DMSO
Storage at -20°C
References

Long-acting testosterone injections for treatment of testosterone deficiency after brachytherapy for prostate cancer.
Balbontin FG, et al. BJU Int. 2014 Jul;114(1):125-30. PMID: 25101359.

The response to testosterone undecanoate in men with type 2 diabetes is dependent on achieving threshold serum levels (the BLAST study).
Hackett G, et al. Int J Clin Pract. 2014 Feb;68(2):203-15. PMID: 24355040.

Related Androgen Receptor Products
Lubiprostone

Lubiprostone is an orally active prostone that locally and selectively activates ClC-2 chloride channels to enhance the intestinal fluid secretion without altering the serum electrolyte levels.

Nandrolone phenylpropionate

Nandrolone phenylpropionate (NPP) is an anabolic-androgenic steroid. The low androgenicity and enhanced anabolic activity of NPP has shown to positively influence calcium metabolism and to increase bone mass in osteoporosis.

ChlordehydroMethyl Testosterone

Testosterone is normally present in the circulation of both men and women. Due to the dynamic regulation of endogenous testosterone production, including the acute effects of competition and exercise, testosterone concentrations may vary considerably within and among individuals.

Testosterone phenylpropionate

Testosterone phenylpropionate is a synthetic anabolic-androgenic steroid (AAS) and an androgen ester.

Testosterone isocaproate

Testosterone Isocaproate help in increasing the body weight and will also help in gaining the strength and also help in losing fat in the body and gives an increase in libido, red blood cells, stamina and quick recovery after heavy training.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Testosterone, (+)-Testosterone supplier, Androgen Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.