Testosterone modulates vascular endothelial cell (EC) growth and platelet aggregation through its direct action on endothelial NO production. Testosterone stimulates NO synthesis via its direct action on ECs. Testosterone involves a nongenomic stimulation of NO synthesis, which depends on calcium influx from the extracellular medium and on MAPK and PKC pathways. Testosterone increases EC growth in bovine aortic and in vein ECs. Testosterone stimulates EC migration. Testosterone stimulates VEGF and NOS expression and promotes capillary formation in the cerebral vascular system. In fact, in bovine aortic ECs, Testosterone and DHEA promote EC proliferation, migration, and vascular tube formation, effects dependent on PTX-sensitive G protein and ERK1/2 activation.
J Transl Med. 2023 Feb 18;21(1):129.
Anti-oncogenic effects of dutasteride, a dual 5-alpha reductase inhibitor and a drug for benign prostate hyperplasia, in bladder cancer
Testosterone purchased from AbMole
Cell Commun Signal. 2022 May 9;20(1):61.
Follicular fluid-derived exosomal miR-143-3p/miR-155-5p regulate follicular dysplasia by modulating glycolysis in granulosa cells in polycystic ovary syndrome
Testosterone purchased from AbMole
J Steroid Biochem Mol Biol. 2013 Nov;138:54-62.
Effect of androgens on different breast cancer cells co-cultured with or without breast adipose fibroblasts
Testosterone purchased from AbMole
| Molecular Weight | 288.42 |
| Formula | C19H28O2 |
| CAS Number | 58-22-0 |
| Solubility (25°C) | 52 mg/mL in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Androgen Receptor Products |
|---|
| BMS-986365
BMS-986365 (CC-94676) is a selective heterobifunctional ligand-directed degrader (LDD) with a dual mechanism-of-action and best-in-class potential, targeting the androgen receptor (AR). In animal models of advanced prostate cancer, BMS-986365 demonstrates on-target activity, degrading AR, suppressing AR signaling, and inhibiting tumor growth. |
| Androstenone
Androstenone is a steroid pheromone and also a metabolite of androgens. |
| (Des-Glu5)-ACTH (1-24) (human, bovine, rat)
(Des-Glu5)-ACTH (1-24) (human, bovine, rat) is an analogue of Adrenocorticotropic hormone (ACTH). |
| Acetyl-ACTH (2-24) (human, bovine, rat)
Acetyl-ACTH (2-24) (human, bovine, rat) is a fragment of proopiomelanocortin (POMC) peptide. |
| Acetyl-ACTH (3-24) (human, bovine, rat)
Acetyl-ACTH (3-24) (human, bovine, rat) is a fragment of proopiomelanocortin (POMC) peptide. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
