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Cat. No. M6105
Testosterone Structure


Size Price Availability Quantity
100mg USD 80 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Testosterone modulates vascular endothelial cell (EC) growth and platelet aggregation through its direct action on endothelial NO production. Testosterone stimulates NO synthesis via its direct action on ECs. Testosterone involves a nongenomic stimulation of NO synthesis, which depends on calcium influx from the extracellular medium and on MAPK and PKC pathways. Testosterone increases EC growth in bovine aortic and in vein ECs. Testosterone stimulates EC migration. Testosterone stimulates VEGF and NOS expression and promotes capillary formation in the cerebral vascular system. In fact, in bovine aortic ECs, Testosterone and DHEA promote EC proliferation, migration, and vascular tube formation, effects dependent on PTX-sensitive G protein and ERK1/2 activation[1] The calculated EC50 value of morning Testosterone corresponding to a 50% increase in the pubertal growth ratio is 3.1 nM (2.4-4.2, r2=0.84) using the dose-response model. Growth velocity increases by 50% from prepubertal growth to PHV at a morning Testosterone level of 3.1 nM (95% confidence interval 2.4-4.2), EC50.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 288.42
Formula C19H28O2
CAS Number 58-22-0
Purity >99%
Solubility 52 mg/mL in DMSO
Storage at -20°C

Long-acting testosterone injections for treatment of testosterone deficiency after brachytherapy for prostate cancer.
Balbontin FG, et al. BJU Int. 2014 Jul;114(1):125-30. PMID: 25101359.

The response to testosterone undecanoate in men with type 2 diabetes is dependent on achieving threshold serum levels (the BLAST study).
Hackett G, et al. Int J Clin Pract. 2014 Feb;68(2):203-15. PMID: 24355040.

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