Chloroquine is an inhibitor of autophagy and Toll-like receptors (TLRs). Chloroquine can effectively inhibit SARS-COV-2 infection (EC50=1.13 μM). Chloroquine is an anti-inflammatory widely used in malaria and rheumatoid arthritis.
Front Immunol. 2023 Mar 14;14:1120996.
ROS-AMPK/mTOR-dependent enterocyte autophagy is involved in the regulation of Giardia infection-related tight junction protein and nitric oxide levels
Chloroquine purchased from AbMole
Arch Oral Biol. 2023 Apr 18;151:105700.
Wrinkled topography regulates osteogenesis via autophagy-mediated Wnt/β-catenin signaling pathway in MC3T3-E1 cells
Chloroquine purchased from AbMole
Journal of Clinical Hepatology. 2023 Sep;p2103-2109.
Mechanistic studies on the regulation of non-alcoholic fatty liver disease by growth differentiation factor 11
Chloroquine purchased from AbMole
J Clin Hepatol. 2023 Sep;Vol. 39.
Mechanism of growth differentiation factor 11 regulating nonalcoholic fatty liver disease
Chloroquine purchased from AbMole
Ecotoxicol Environ Saf. 2022 Jun 1;237:113564.
Environmental BPDE induced human trophoblast cell apoptosis by up-regulating lnc-HZ01/p53 positive feedback loop
Chloroquine purchased from AbMole
Adv Sci (Weinh). 2021 Feb.
Inhibition Lysosomal Degradation of Clusterin by Protein Kinase D3 Promotes Triple‐Negative Breast Cancer Tumor Growth
Chloroquine purchased from AbMole
Life Sci. 2020 Nov 15;261:118484.
Chloride channel 7 protects from redox status impairment-induced renal tubular epithelial cell apoptosis by activating autophagy
Chloroquine purchased from AbMole
Int J Neurosci. 2020 Mar 11;1-15.
Autophagy-deficiency in Bone Marrow Mononuclear Cells From Patients With Myasthenia Gravis: A Possible Mechanism of Pathogenesis.
Chloroquine purchased from AbMole
Anat Rec (Hoboken). 2020 Jan 21.
Resibufogenin inhibited colorectal cancer cell growth and tumorigenesis through triggering ferroptosis and ROS production mediated by GPX4 inactivation
Chloroquine purchased from AbMole
Molecular Weight | 319.87 |
Formula | C18H26ClN3 |
CAS Number | 54-05-7 |
Solubility (25°C) | DMSO ≥ 50 mg/mL |
Storage | 4°C, dry, protect from light, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Winnie Fong, et al. Repurposing Chloroquine Analogs as an Adjuvant Cancer Therapy
[4] Bruno Mgarbane. Chloroquine and hydroxychloroquine to treat COVID-19: between hope and caution
Related Autophagy Products |
---|
Sofalcone
Sofalcone is a gastric antiulcer agent, it is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium. |
P62-mediated mitophagy inducer
P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. |
FDW028
FDW028 is a potent and highly selective FUT8 inhibitor. FDW028 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the CMA pathway. |
Calmodulin-Dependent Protein Kinase II (290-309)
Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. |
Microcolin H
Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.